Quaternary ammonium carbon quantum dots as an antimicrobial agent against gram-positive bacteria for the treatment of MRSA-infected pneumonia in mice

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Where Is the Artificial Intelligence Applied in Dentistry? Systematic Review and Literature Analysis

Effect of the photoinitiator system on the polymerization of secondary methacrylamides of systematically varied structure for dental adhesive applications.

Three-dimensional (3D) additive manufacturing (AM) is an evolving technology in dentistry, proposed as an alternative to subtractive milling manufacture (MM) or conventional processing. However, a systematic review of the use of AM technology instead of milling or conventional processing is lacking.The purpose of this systematic review and meta-analysis was to evaluate the mechanical properties of 3D-printed prosthetic materials compared with MM and conventional techniques.An electronic search of the literature was conducted on the MEDLINE (via PubMed), Scopus, and Web of Science databases. The inclusion criteria were in vitro studies published in the last 5 years, in English or Italian, and with 3D AM printed dental prosthetic materials. Data extraction was focused on dental prosthetic materials (ceramics, polymers, and metals) and their mechanical properties: flexural strength, fracture load, hardness, roughness, removable partial denture (RPD) fit accuracy, trueness, marginal discrepancy, and internal fit. Data considered homogenous were subjected to meta-analysis using the Stata17 statistical software program (95% confidence interval [CI]; α=.05). Since all variables were continuous, the Hedge g measure was calculated. A fixed-effects model was used for I2=0%, while the statistical analysis was conducted using a random-effects model with I2>0%.From a total of 3624 articles, 2855 studies were selected, and 76 studies included after full-text reading. The roughness of AM-printed ceramics generally increased compared with that of conventional processing while the marginal discrepancy was comparable both for ceramics and polymers. The flexural strength, hardness, and fracture load of AM-printed polymers were statistically lower than those of the conventional group (P<.05). No significant difference was detected in terms of hardness, roughness, marginal discrepancy, fracture load, trueness, or internal fit between the AM and MM techniques (P>.05). Milling techniques showed significantly higher values of flexural strength (Hedge g=-3.88; 95% CI, -7.20 to -0.58; P=.02), also after aging (Hedge g=-3.29; 95% CI, -6.41 to -0.17; P=.04), compared with AM printing.AM is comparable with MM in terms of mechanical properties, in particular with polymeric materials. The flexural strength of AM-printed prostheses is lower than with conventional and MM techniques, as are the parameters of hardness and fracture load, while the marginal discrepancy is similar to that of MM and conventional techniques. AM prostheses are commonly used for interim crowns and fixed partial dentures, as their rigidity and fracture resistance cannot support mastication forces for extended periods. More comparative studies are needed. 

Mechanical properties of 3D-printed prosthetic materials compared with milled and conventional processing: A systematic review and meta-analysis of in vitro studies.

Marginal gap and fracture resistance of implant-supported 3D-printed definitive composite crowns: an in vitro study.

This study evaluated the cytotoxicity of resin-based luting cements on fibroblast cells using different polymerization protocols. Two conventional dual-polymerized (RelyX ARC, VariolinkN) and two self-adhesive resin cements (RelyX Unicem, Multilink Speed) specimens were polymerized using four different polymerization protocols: (a) photo-polymerization with direct light application, (b) photo-polymerization over ceramic and (c) resin nano-ceramic discs and (d) auto-polymerization. The specimens were then assigned to four groups to test cytotoxicity at 0, 1, 2 and 7 preincubation days (n = 5). MTT test was performed using NIH/3T3 fibroblast cells. Data were analysed using three- and one-way ANOVA. Multiple comparisons were made using Bonferroni post hoc test (p   0.05). Cytotoxicity of dual-polymerized resin cements was material-dependent and decreased gradually up to 7 days. Photo-polymerization plays an important role in reducing the cytotoxic effects. When luting ceramic or resin nano-ceramic restorations of which thickness does not exceed 2 mm, the level of cytotoxicity with the tested materials is not significant. Luting of restorative materials that do not allow for light transmission such as metal-fused porcelain, clinicians should be cautious in the use of dual-polymerized conventional resin cements as only auto-polymerization of resin cements takes place under such materials.

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Effect of various polymerization protocols on the cytotoxicity of conventional and self-adhesive resin-based luting cements

Purpose An in vitro study to compare the adaptation of denture bases fabricated with 4 different techniques using volumetric 3-dimentional (3D) analysis. Material and methods Edentulous maxillary and mandibular casts were scanned, and standardized denture bases were designed using CAD design software. The same standard tessellation language (STL) data were used to produce the denture bases with 4 different fabrication methods: compression molding (CM), injection molding (IM), PMMA milling (PM), and 3D printing (3D) (n = 11/group). Milled wax denture bases were used to fabricate CM and IM groups. Denture bases placed on edentulous casts were scanned using micro-computed tomography (micro-CT). Volumetric gap between denture base and cast was calculated from 6 locations for maxilla (anterior ridge crest, posterior ridge crest, labial vestibule, buccal vestibule, palate, and posterior palatal seal) and 3 locations for mandible (intermolar, molar, and retromolar) in addition to overall gap measurements for edentulous arches. The data were analyzed with factorial analysis of variance (ANOVA), 1-way ANOVA, and post-hoc Duncan tests. Reproducibility of fabrication methods with regard to each location was assessed using Z test (α = 0.05). Results In the maxilla, the highest and lowest palatal gap measurements were recorded for CM (898.44 ± 87.73 mm3 ) and PM (357.16 ± 57.68 mm3 ) (p = 0.05). The highest gap measurements for CM and 3D were at palate and, for IM and PM were at posterior ridge crest. In mandible, the volumetric gap measurements for CM were the highest and for PM were the lowest irrespective of location (p = 0.05). PM group showed the best reproducibility and adaptation with the lowest overall mean gaps for both edentulous arches (p = 0.05). Conclusions Denture bases milled from PMMA blocks showed better adaptation than 3D printed, or wax milled and conventionally fabricated denture bases for both maxillary and mandibular arches. PMMA milling is a reproducible technique that enables the construction of accurate dentures. Clinicians should be cautious about the palatal gap when the compression molding technique is used. Micro-CT is a valid technique for evaluating the denture base adaptation.

Evaluation of Denture Base Adaptation Fabricated Using Conventional, Subtractive, and Additive Technologies: A Volumetric Micro-Computed Tomography Analysis.

The aim of this study was to compare the fit of feldspathic ceramic crowns fabricated via 3 different extraoral digitizing methods. Twelve maxillary first premolars were prepared and 36 single crowns were fabricated via 3 extraoral digitizing methods using a laboratory scanner (n = 12): (1) scanning the typodont (ST [control] group); (2) scanning the impression (SI group); (3) scanning the stone cast (SC group). Micro-computed tomography was used to calculate two-dimensional marginal-internal gap and the three-dimensional volumetric gap between the crowns and their corresponding dies. The measured gaps were divided into 6 location categories as follows: marginal gap (MG), finish line gap (FLG), axial wall gap (AWG), cuspal gap (CG), proximal transition gap (PTG), and central fossa gap (CFG). The correlation between each of the 3 extraoral digitizing methods and the adaptation status of the crown margins were also evaluated. The Wilcoxon signed-rank test, Spearman’s rank test, and Chi-square test were used for data analysis (α = 0.05). The marginal gaps in the ST, SI, and SC groups differed significantly (24, 198 and 117.6 µm, respectively) (p   0.05). Under-extended margins observed in the SI and SC groups were correlated with the digitizing method (Cramer’s V-square: 0.14). When performing extraoral digitalization, clinicians should choose to scan the stone cast as scanning the stone cast resulted in better internal and marginal fit compared to scanning the impression.

Marginal and internal fit of feldspathic ceramic CAD/CAM crowns fabricated via different extraoral digitization methods: a micro-computed tomography analysis

Statement of problem Studies assessing the comparative denture base adaptation performance of the pour technique for various palatal vault depths are sparse. Purpose The purpose of this in vitro study was to investigate the denture base adaptation performance of the pour technique compared with other conventional fabrication techniques (light-polymerization, injection, compression molding) for shallow and deep palatal vault depths. Material and methods Edentulous maxillary study models with 2 palatal vault depths were prepared. Based on the power analysis, the sample size of each conventional fabrication technique was 12 (N=96). After denture bases for each technique had been fabricated on the casts according to the manufacturers’ recommendations, the casts and the intaglio surfaces of the denture bases were scanned by using a laboratory scanner (InEos X5). The standard tessellation language (STL) files of the casts and the intaglio surfaces of acrylic resin bases were transferred into a software program (Romexis, version 5.0), and the software superimposed each cast and its corresponding denture base scan with the reference pyramids semi-automatically. After superimposition, the mean gap distances (mm) were calculated by using the software and recorded from the identified 4 specific regions (denture border apex, palate, ridge crest, and posterior palatal seal). A statistical analysis was performed by using the 3-factor factorial ANOVA. Post hoc comparisons among the subgroups were performed by using the Tukey HSD test. Results Two- and 3-way interactions among palatal vault depth, polymerization technique, and location variables were statistically significant (P .05). The light-polymerization technique showed the highest mean gap distances among the tested polymerization techniques in all regions except for the posterior palatal seal area (P Conclusions The pour technique showed similar denture base adaptation to compression molding and injection. Light-polymerization exhibited the highest mean gap distance between the denture base and the cast for both palatal vault depths for most of the locations. A deep palatal vault depth led to inferior denture base adaptation performance for light-polymerization in the ridge crest and compression molding in the posterior palatal seal location.

Comparative analysis of denture base adaptation performance between pour and other conventional fabrication techniques.

Purpose The aim of this study was to evaluate the effect of multiple firings on the bond strength between yttria-tetragonal zirconia polycrystals (Y-TZP) and 2 types of resin cements. Materials and methods Sixty 3Y-TZP specimens (LAVA Frame Multi) were divided into 3 groups depending on the following firing procedures: (1) 2-firing cycles, (2) 5-firing cycles, (3) 10-firing cycles. Two samples from each group were investigated by using SEM to determine the morphological changes. All specimens were treated with 125 µm airborne-particle abrasion and the surface roughness of each specimen was measured. The specimens from each firing group were then further divided into 2 subgroups (n = 9) to apply 2 types of resin cement (MDP-free resin cement: RelyX Unicem-RU, and MDP containing resin cement: Panavia F 2.0-PA). The shear bond strength (SBS) test was performed and failure types of all the debonded specimens were classified by using a stereomicroscope as adhesive, cohesive, and mixed. The statistical analysis of surface roughness and SBS data were performed by using 1-way ANOVA and 2-way ANOVA followed by Tukey-HSD tests (α=.05). Failure modes were calculated as a percentage for each group. Results The bond strength of RU and PA to the specimens obtained with 2 firings were not statistically different from each other (P=.1). However, the SBS values of PA were found to be significantly higher than RU for the specimens obtained with 5 and 10 firing cycles (P=.001 and P=.02, respectively). Surface roughness analysis revealed no statistical difference between groups (P=.2). The SEM analysis of samples fired 5- and 10- times showed irregularities and boundary loss in zirconia grains, and empty spaces between zirconia grains. Conclusion The bond strength of PA cement was higher than that of RU to the zirconia subjected to repeated firings (5 and 10 firing cycles). When zirconia is subjected to multiple firings, using MDP-containing resin cement can be recommended.

Ece Irem Oguz

Papers

Effect of various polymerization protocols on the cytotoxicity of conventional and self-adhesive resin-based luting cements

Evaluation of Denture Base Adaptation Fabricated Using Conventional, Subtractive, and Additive Technologies: A Volumetric Micro-Computed Tomography Analysis.

Marginal and internal fit of feldspathic ceramic CAD/CAM crowns fabricated via different extraoral digitization methods: a micro-computed tomography analysis

Comparative analysis of denture base adaptation performance between pour and other conventional fabrication techniques.

Impact of multiple firings and resin cement type on shear bond strength between zirconia and resin cements.