The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1 Neovascularization (angiogenesis) is also implicated in the pathogenesis of a number of disorders These include: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis1,2 A strong correlation has been noted between density of microvessels in primary breast cancers and their nodal metastases and patient survival3 Similarly, a correlation has been reported between vascularity and invasive behavior in several other tumors4–6

The biology of vascular endothelial growth factor

Anticoagulant drugs in the treatment of pulmonary embolism. a controlled trial

Table of contents Preamble Scope of the document 1256 Method 1257 Part 1. Classification, epidemiology and prognosis Definition 1258 Brief overview of pathophysiology of syncope 1258 Classification 1259 Epidemiological considerations 1259 Prognostic stratification: identification of factors predictive of adverse outcome 1260 Part 2. Diagnosis Strategy of evaluation (flow chart) 1262 Initial evaluation (history, physical examination, baseline electrocardiogram) 1264 Echocardiogram 1266 Carotid sinus massage 1266 Tilt testing 1268 Electrocardiographic monitoring (non-invasive and invasive) 1271 Electrophysiological testing 1273 ATP test 1277 Ventricular signal-averaged electrocardiogram 1278 Exercise testing 1278 Cardiac catheterization and angiography 1279 Neurological and psychiatric evaluation 1279 Diagnostic yield and prevalence of causes of syncope 1282

Guidelines on management (diagnosis and treatment) of syncope

Natural history of pulmonary embolism

ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary : a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias).

https://cdr.lib.unc.edu/downloads/x920fz917

ACC/AHA/ESC Guidelines for the Management of Patients with Supraventricular Arrhythmias - Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients with Supraventricular Arrhythmias)

Presents an organized approach to diagnosis and treatment in connection with problems of the ageing spine. Current concepts of the biochemical, biomechanical and histologic aspects of spinal ageing and degeneration are included.

Peripheral Vascular Diseases

Raynaudʼs disease: a critical review of minimal requisites for diagnosis.*

Excerpt There is little in the literature on abnormal localized depositions of body fat to clarify the syndrome of lipedema of the legs which two of us (E. V. A. and E. A. H.) described in 1940.1Co...

Lipedema of the legs: a syndrome characterized by fat legs and edema

Orthostatic hypotension is characterized chiefly by a sharp decrease in blood pressure when a patient afflicted with it stands. The blood pressure is ordinarily normal when the patient lies. If the blood pressure decreases to a low level, weakness and syncope result. Other relevant signs or symptoms are deficient sweating, either localized or generalized, secretion of larger amounts of urine when the patient is recumbent than when he is erect and in some cases a failure of the pulse rate to increase markedly when the patient assumes the erect posture. Orthostatic hypotension should be suspected whenever a patient has exhaustion in the morning which lessens during the day, whenever weakness, dimness of vision or syncope occurs on assumption of the erect posture and disappears on lying down, whenever episodes of syncope are inadequately explained and whenever there is diminished sweating. This condition has been considered by some to be the

Orthostatic hypotension and orthostatic tachycardia: treatment with the head-up bed

It has been known for many years by veterinarians and cattle raisers that cattle fairly frequently and for no apparent reason bleed considerably and perhaps fatally. Studies of this condition were made originally and independently in 1921 by Schofield1in Canada and by Roderick2in this country. They determined that this hemorrhagic disease arises from eating improperly cured hay or silage made from the common sweet clovers. It was recognized early that if the hemorrhagic manifestations had not proceeded too far the hemorrhage could be controlled by withdrawal of the spoiled hay from the diet or by the injection of freshly drawn blood serum of healthy animals.3At first it was thought that the liver was damaged by the ingested spoiled hay, but this could not be confirmed by Roderick. However, he noted that the delayed coagulability of the blood involved a reduction in the prothrombin content

https://jamanetwork.com/HttpHandlers/ArticlePdfHandler.ashx?journal=jama&articleId=258678&pdfFileName=jama_120_13_004.pdf

A PREPARATION FROM SPOILED SWEET CLOVER: [3,3′-Methylene-Bis-(4-Hydroxycoumarin)] Which Prolongs Coagulation and Prothrombin Time of the Blood: A Clinical Study

Edgar V. Allen

Papers

Peripheral Vascular Diseases

Raynaudʼs disease: a critical review of minimal requisites for diagnosis.*

Lipedema of the legs: a syndrome characterized by fat legs and edema

Orthostatic hypotension and orthostatic tachycardia: treatment with the head-up bed

A PREPARATION FROM SPOILED SWEET CLOVER: [3,3′-Methylene-Bis-(4-Hydroxycoumarin)] Which Prolongs Coagulation and Prothrombin Time of the Blood: A Clinical Study