Edith Olah

TL;DR: The results are in line with earlier ones in this Laboratory on solid tumors indicating an integrated imbalance of the key enzymes of pyrimidine, purine and carbohydrate metabolism that should confer selective advantages to cancer cells.

TL;DR: The pattern displayed revealed an integrated program of changes in activities of opposing key enzymes of thymidine metabolism, in Activities of various pyrimidine enzymes, in incorporation of precursors and in the concentration of the nucleotides.

TL;DR: The striking increases in the activities of CTP synthetase, OMP decarboxylase, glutamine PRPP amidotransferase and thymidine kinase mark out these enzymes as potentially sensitive targets for combination chemotherapy by specific inhibitors of these enzyme activities.

TL;DR: It was demonstrated that this drug exerted a clearcut, phase-specific toxicity and was particularly toxic to early G1 and early S phase cells, but had little or no effect on tumor cells in other phases of the cell cycle.

TL;DR: Inhibition by quercetin of the enhanced capacity for operation of signal transduction in human ovarian carcinoma cells is demonstrated for the first time, thus providing a novel target in cancer cells.