Edward B. Caref

TL;DR: High-resolution tridimensional isochronal mapping of both activation and repolarization patterns in puppies exposed to AP-A that developed LQTS and polymorphic ventricular tachyarrhythmias (VTs) shows that the initial beat of polymorphic VT consistently arose as focal activity from a subend cardiac site, whereas subsequent beats were due to successive subendocardial focal activity, reentrant excitation, or a combination of both.

TL;DR: The cellular studies showed that reentrant excitation secondary to dispersion of repolarization and triggered activity from both early and delayed afterdepolarizations are potential mechanisms for VT in the post-MI remodeled heart.

TL;DR: Detailed analysis of ventricular tridimensional activation patterns during nonsustained TdP VT was performed to provide an EP mechanism of the characteristic periodic transition in QRS axis for the first time.

TL;DR: The arrhythmogenicity of QT/T alternans was primarily due to the greater degree of spatial dispersion of repolarization during alternans than during slower rates not associated withAlternans, which could result in functional conduction block and reentrant ventricular tachyarrhythmias during the fixed drive associated with alternans.

TL;DR: In patients with nonischemic dilated cardiomyopathy, there is a strong correlation between abnormal findings on the time-domain signal-averaged ECG and induced ventricular tachycardia, but both findings are uncommon.