Edward D. Plowey

TL;DR: In this paper, the tertiary eigenvector of structure tensors is used to estimate the three-dimensional neuronal fiber and vasculature orientations from neurofilament stained CLARITY images, and then the orientation estimates are extended to an orientation distribution function (ODF) formalism by summing multiple sub-voxel orientation estimates.

TL;DR: The cross-sectional autopsy findings indicate that the fornix is involved by p-MAPT neuropathology secondary to hippocampal involvement by AD neuro Pathology, and are compatible with the goal of in vivo detection of p- MAPT-related axonal pathology in theFornix in AD as a possible biomarker of p -MAPT progression from the hippocampal formation.

TL;DR: In this paper, GA binding protein (GABP) was identified as a transcriptional regulator of the combinatorial expression of BECN1-PIK3C3 complex genes involved in autophagosome initiation.

TL;DR: In this article , an 84-year-old woman who was randomized to the placebo arm of the PRIME Phase 1b study (221AD103) showed robust Aβ plaque reduction, from a composite standard uptake value ratio (SUVR) of 1.5 at screening to < 1.1 at 56 weeks post-aducanumab dosing.

TL;DR: This is the first known report that describes a case of concomitant CCM and OCH and explores the origins of two pathologies that are rarely encountered together in neurosurgical practice.