E
Edward V. Sargent
Researcher at Merck & Co.
Publications - 24
Citations - 784
Edward V. Sargent is an academic researcher from Merck & Co.. The author has contributed to research in topics: Control banding & Acceptable daily intake. The author has an hindex of 11, co-authored 24 publications receiving 747 citations.
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Journal ArticleDOI
Is Hexavalent Chromium Carcinogenic via Ingestion? A Weight-Of-Evidence Review
Deborah M. Proctor,Joanne M. Otani,Brent L. Finley,Dennis J. Paustenbach,Judith A. Bland,Ned A. Speizer,Edward V. Sargent +6 more
TL;DR: The weight of scientific evidence supports that Cr(VI) is not carcinogenic in humans via the oral route of exposure at permissible drinking-water concentrations.
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A Human Health Risk Assessment of Pharmaceuticals in the Aquatic Environment
Lisa J. Schulman,Edward V. Sargent,Bruce D. Naumann,Ellen C. Faria,David G. Dolan,John P. Wargo +5 more
TL;DR: The overall conclusion was that based on available data, no appreciable risk to humans exists, as the detected concentrations of each of these pharmaceutical compounds found in aqueous media were far below the derived safe limits.
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Performance-based exposure control limits for pharmaceutical active ingredients
TL;DR: The trend in the pharmaceutical industry is to identify and develop more selective drugs of increasing potency, and because of the difficulty in identifying no-effect levels for certain drugs, a new performance-based approach for setting limits was developed.
Journal ArticleDOI
Establishing Airborne Exposure Control Limits in the Pharmaceutical Industry
Edward V. Sargent,G D Kirk +1 more
TL;DR: A procedure for establishing workplace exposure control limits (ECLs) for pharmaceutical products is presented and limits are given for 32 human health drugs.
Journal ArticleDOI
Application of the threshold of toxicological concern concept to pharmaceutical manufacturing operations.
TL;DR: A scientific rationale is provided for estimating acceptable daily intake values (ADIs) for compounds with limited or no toxicity information to support pharmaceutical manufacturing operations and recommendations are provided on ADI values that correspond to three categories of compounds.