Showing papers by "Edythe D. London published in 1984"
TL;DR: Results support the views that cortical metabolic decrements in Alzheimer's disease are due in part to loss of subcortical cholinergic innervation and that muscarinic agonists may partially reverse these decrements.
Abstract: Rats received unilateral injections of ibotenic acid (12 μg) or vehicle in the ventromedial globus pallidus to lesion the primary source of cortical cholinergic innervation. At 3 or 28–32 days postinjection, the regional cerebral metabolic rate for glucose (rCMRglu) was measured by the 2-deoxy-d-[14C]glucose technique in nine cortical areas, the anterior thalamus, and the dorsal hippocampus. Effects of oxotremorine (0.1 mg/kg i.p.) on rCMRglu in these areas were assessed in ibotenic acid–lesioned and sham-treated rats. Significant effects of ibotenic acid injections and hemispheric asymmetries in rCMRglu were observed in all cortical areas (p ≤ 0.05), but not in the anterior thalamus or hippocampus. Cortical rCMRglu generally was lower in the lesioned hemisphere 3 days after ibotenic acid injections, but not after sham treatments. Hemispheric asymmetries were not apparent 28–32 days after pallidal lesions. Oxotremorine produced significant effects in the frontoparietal cortex and anterior thalamic nuclei....
79 citations
TL;DR: The [14C]2-deoxy-D-glucose technique was used to test the effects of central muscarinic stimulation or antagonism on local cerebral glucose utilization (LCGU) in the rat limbic system, and scopolamine blocked these effects, and independently decreased LCGU in the pre- and postsubiculum, anterior thalamic nuclei, and retrosplenial medial cortex.
33 citations
01 Jan 1984
TL;DR: Techniques for assessment of cerebral blood flow and oxidative metabolism in vivo are described, as are results obtained in animal and human studies of age differences in these parameters.
Abstract: Because of the close relationships between cerebral functional activity and measures of cerebral blood flow and metabolism, investigators have used these measures to gain information about altered function in various experimental and pathologic states. This chapter reviews information regarding the associations between cerebral metabolism, blood flow, and function. Also reviewed are results from in vitro studies of oxidative metabolism and glucose metabolism in aging animals. Techniques for assessment of cerebral blood flow and oxidative metabolism in vivo are described, as are results obtained in animal and human studies of age differences in these parameters. The possible advantage of performing measurements on subjects in activated states, rather than the resting state, is discussed.
8 citations