Showing papers in "Brain Research in 1984"

TL;DR: A new neuroanatomical method for tracing connections in the central nervous system based on the anterograde axonal transport of the kidney bean lectin, Phaseolus vulgaris-leucoagglutinin (PHA-L) is described, which offers several advantages over present techniques.

TL;DR: The subnuclear organization of PB is demonstrated, and this with the origins of its efferent connections, and recent immunohistochemical observations suggest that the subnuclear organizations of PB afferent and efferent connection may reflect, at least in part, their biochemical specificity.

TL;DR: 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine appears effective in producing an animal model for Parkinson's disease in the squirrel monkey, and may be one of the more selective neurotoxins described to date.

TL;DR: The results demonstrate that NMDA receptors present in hippocampal region CA1 are not necessary for normal synaptic transmission, but are involved in the initiation of long-term synaptic plasticity.

TL;DR: An evaluation of investigations designed to elucidate regulatory mechanisms at acidic amino acid binding sites is made; hypotheses such as the Ca2+-activated protease hypothesis of long-term potentiation are assessed in terms of the new binding site/receptor classification scheme.

TL;DR: Extensive networks of HDCI fibers of various densities were found in many areas of the brain; they were particularly dense in the hypothalamus but were also found in the following areas: rostrally in the cerebral cortex, olfactory nuclei, medial amygdaloid nucleus, n.

TL;DR: There appears to be a remarkable unity in frontal cortex function across the class mammalia, and it is proposed that the principal function of the prefrontal cortex of mammals is the temporal organization of behavior.

TL;DR: A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described, which becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine.

TL;DR: High selectivity for uptake and retrograde transport of NGF indicates the presence of membrane receptors for NGF or a closely related molecule on these cholinergic neurons of the basal forebrain innervating the cerebral cortex.

TL;DR: It is indicated that spine shape changes are not necessary for the maintenance of LTP, and continuous high frequency activation which does not produce potentiation has different and non-persisting effects from potentiating stimulation.

TL;DR: The combined use of immunohistochemistry with a retrograde fluorescent tracer, True Blue, indicated that the peptide-containing perikarya are found predominantly in the lateral part of ACe (ACe1), and that only a small proportion of neurotensin, somatostatin and corticotropin-releasing factor-stained neurons contained True Blue after injections into the PB or the DVC.

TL;DR: It is suggested that alphaxalone and pentobarbitone share a common mode of action on the GABA system, which may be relevant to the mechanisms by which these drugs produce anaesthesia.

TL;DR: Findings indicate that the cortical and dopaminergic nigral efferents have actions on common recipient neurons in the rat caudate nucleus and provide support for a possible direct axonal interrelationship between these two primary inputs.

TL;DR: The lack of effect on AChE strongly suggests that the increases in ChAT activity in hippocampus and septum are due to an elevation of Chat activity within cholinergic neurons surviving the lesion rather than to a promotion of sprouting of Cholinergic fibers.

TL;DR: Light microscopic autoradiography showed that cultured granule cells and their processes can accumulate the glutamate analog [3H]D-aspartate once they have reached an advanced degree of morphological differentiation, but, even then, only a limited number of cells was heavily labeled.

TL;DR: Results indicate that proprioceptive input from skin, pressure and joint receptors of the foot (ischemia at the ankle) is of minor importance for the compensation of rapid displacements, but plays a significant role when the platform moves at low frequencies.

TL;DR: It is proposed that systemic pilocarpine in mice provides a useful animal model for studying mechanisms of and therapeutic approaches to temporal lobe epilepsy and the results emphasize that excessive and sustained stimulation of cholinergic receptors can lead to seizures and seizure-related brain damage in mice.

TL;DR: The results indicate that the cerebellum is an essential structure for the behavioral expression of learning, and plays an important role in the generation of conditioned hippocampal responses observed in this paradigm.

TL;DR: It is demonstrated that fibers from both regions descend through the medial forebrain bundle and give rise in the pedunculopontine nucleus to a terminal field that contains many structures with the appearance of terminal boutons.

TL;DR: Regional differences in the molecular composition of the neuronal cytoskeleton can develop independently of cell interactions, and the presence of MAP2 may be a useful marker for identifying dendrites in cell culture.

TL;DR: The use of the fluorescence retrograde double-labeling method has revealed that striatal neurons projecting to the globus pallidus in the squirrel monkey are mainly confined to the putamen whereas those projection to the substantia nigra occur mostly in the caudate nucleus.

TL;DR: Cortical projections to the region of the noradrenergic locus coeruleus (LC) and the serotonergic dorsal and central superior raphe nuclei were analyzed in the rhesus monkey using anterograde labeling techniques to suggest that the dorsal prefrontal cortex may be the only cortical area to have direct influence on the LC and rapheuclei and secondary influence onThe monoaminergic innervation of large areas of cerebral cortex.

TL;DR: The efferent and afferent connections of the supplementary motor area (SMA) were studied in 6 squirrel monkeys using [3H]leucine and horseradish peroxidase, respectively with respect to the possible role SMA plays in the voluntary initiation of motor actions.

TL;DR: Use of the modified reaction with HRP conjugated wheat germ agglutinin (WGA-HRP) yields a powerful technique for anterograde and retrograde tracing.

TL;DR: Data show that CaBP is widely distributed in neurons and ependymal cells from the rat central nervous system although it is more concentrated in some specific areas.

TL;DR: The data suggest that the LVFA which is normally present in the neocortex during waking Type 2 behavior is dependent on a cholinergic input to the neoc cortex from the substantia innominata.

TL;DR: These studies demonstrate the presence of the MLR in the rat brain by induced controlled locomotion on a treadmill of an area in the posterior midbrain following a precollicular-prenigral brainstem transection.

TL;DR: The results indicate that 5-HT1 receptors are heterogeneous, and that [3H]PAT recognizes only a 5-ht1 subclass (called 5- HT1A).

TL;DR: The results indicate that the nucleus raphe magnus is not a necessary bulbar relay in a descending antinociceptive pathway activated by stimulation in the midbrain periaqueductal gray; and descending inhibitory pathways activated in the perianal gray course medially as well as laterally in the rat ventral medulla.