E
Eero Castrén
Researcher at University of Helsinki
Publications - 285
Citations - 20559
Eero Castrén is an academic researcher from University of Helsinki. The author has contributed to research in topics: Tropomyosin receptor kinase B & Neurotrophic factors. The author has an hindex of 69, co-authored 265 publications receiving 18668 citations. Previous affiliations of Eero Castrén include Max Planck Society & Columbia University.
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Journal ArticleDOI
The antidepressant fluoxetine restores plasticity in the adult visual cortex.
José Fernando Maya Vetencourt,Alessandro Sale,Alessandro Viegi,Laura Baroncelli,Roberto De Pasquale,Olivia F. O’Leary,Eero Castrén,Lamberto Maffei +7 more
TL;DR: It is found that chronic administration of fluoxetine reinstates ocular dominance plasticity in adulthood and promotes the recovery of visual functions in adult amblyopic animals, as tested electrophysiologically and behaviorally.
Journal ArticleDOI
The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity.
Eero Castrén,Tomi Rantamäki +1 more
TL;DR: A model whereby the effects of antidepressant treatments could be explained by a reactivation of activity‐dependent and BDNF‐mediated cortical plasticity, which in turn leads to the adjustment of neuronal networks to better adapt to environmental challenges is suggested.
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Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
Tommi Saarelainen,Panu Hendolin,Guilherme de Araújo Lucas,Eija Koponen,Mikko Sairanen,Ewen MacDonald,Karin Agerman,Annakaisa Haapasalo,Hiroyuki Nawa,Raquel Aloyz,Patrik Ernfors,Eero Castrén +11 more
TL;DR: The data suggest that antidepressants acutely increase trkB signaling in a BDNF-dependent manner in cerebral cortex and that this signaling is required for the behavioral effects typical of antidepressant drugs.
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Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus.
TL;DR: It is observed that chronic treatment with imipramine or fluoxetine produced a temporally similar increase in both BrdU-positive and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end-labeled neurons in the dentate gyrus, indicating that these drugs simultaneously increase both neurogenesis and neuronal elimination.
Journal ArticleDOI
Role of neurotrophic factors in depression.
TL;DR: One hypothesis emerging from data proposes that mood disorders reflect failed function of critical neuronal networks, whereas a gradual network recovery through activity-dependent neuronal plasticity induces the antidepressant effect.