E
Ewen MacDonald
Researcher at University of Eastern Finland
Publications - 103
Citations - 4534
Ewen MacDonald is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Atipamezole & Medetomidine. The author has an hindex of 35, co-authored 101 publications receiving 4387 citations. Previous affiliations of Ewen MacDonald include University of Turku.
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Journal ArticleDOI
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
Tommi Saarelainen,Panu Hendolin,Guilherme de Araújo Lucas,Eija Koponen,Mikko Sairanen,Ewen MacDonald,Karin Agerman,Annakaisa Haapasalo,Hiroyuki Nawa,Raquel Aloyz,Patrik Ernfors,Eero Castrén +11 more
TL;DR: The data suggest that antidepressants acutely increase trkB signaling in a BDNF-dependent manner in cerebral cortex and that this signaling is required for the behavioral effects typical of antidepressant drugs.
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Gene targeting — homing in on α2-adrenoceptor-subtype function
TL;DR: How several strains of genetically engineered mice may be utilized to elucidate the physiological functions of the receptor subtypes and the properties of future subtype-selective drugs is described.
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Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent.
TL;DR: Some of the Fusarium mycotoxin-induced changes in neurochemistry and serum Ig concentrations can be prevented by the feeding of yeast cell wall polymer at appropriate concentrations, although this was not reflected in increased growth rate under these experimental conditions.
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Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist
Jukka Sallinen,Richard E. Link,Antti Haapalinna,Timo Viitamaa,Maya Kulatunga,Birgitta Sjöholm,Ewen MacDonald,Markku Pelto-Huikko,Tiina Leino,Gregory S. Barsh,Brian K. Kobilka,Mika Scheinin +11 more
TL;DR: The effects of dexmedetomidine, a subtype-nonselective α 2 -AR agonist, on monoamine turnover in brain and on locomotor activity were similar in mice with targeted inactivation of the α 2C -AR gene, but the hypothermic effect was significantly attenuated by the receptor gene inactivation.
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Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines.
TL;DR: The data suggest that trkB activation may play a critical role in the behavioral responses to antidepressant drugs in mice, and that brain-derived neurotrophic factor influences the growth and plasticity of serotonergic neurons via the activation of trkB receptor.