E
Eileen Mary Seward
Researcher at Genentech
Publications - 55
Citations - 2044
Eileen Mary Seward is an academic researcher from Genentech. The author has contributed to research in topics: Receptor antagonist & Trifluoromethyl. The author has an hindex of 26, co-authored 55 publications receiving 1972 citations. Previous affiliations of Eileen Mary Seward include Merck & Co. & Charles River Laboratories.
Papers
More filters
Journal ArticleDOI
Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice
Nadia M.J. Rupniak,E.C Carlson,T. Harrison,B. Oates,Eileen Mary Seward,Simon Neil Owen,C De Felipe,Stephen P. Hunt,Alan Wheeldon +8 more
TL;DR: In normal mouse pups, GR205171 attenuated neonatal vocalisations when administered at a high dose (30 mg/kg) only, consistent with its lower affinity for the rat than the guinea-pig NK(1) receptor.
Journal ArticleDOI
Chemical Double-Mutant Cycles for the Measurement of Weak Intermolecular Interactions: Edge-to-Face Aromatic Interactions†
Journal Article
Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.
Margaret A. Cascieri,E. Ber,Tung Ming Fong,S. Sadowski,A. Bansal,Christopher John Swain,Eileen Mary Seward,Bernard Frances,D. Burns,C. D. Strader +9 more
TL;DR: The data suggest that the pharmacological properties of [125I]L-703606 binding to the human NK1 receptor are similar to those of antagonists of nonpeptide guanine nucleotide-binding protein-coupled receptors and that this ligand will be useful for the biochemical and pharmacological characterization of the humanNK1 receptor.
Patent
Substituted morpholine derivatives and their use as therapeutic agents
Raymond Baker,Timothy Harrison,Angus Murray Macleod,Andrew Pate Owens,Eileen Mary Seward,Christopher John Swain,Martin Richard Teall +6 more
TL;DR: In this article, the present invention relates to compounds of formula (I), wherein R 1 is hydrogen, halogen, C?1-6? alkyl, C? 1-4? alkoxy, CF3, NO2, CN, SR?a, SORa, SO?2Ra, CO2R?a, CONRaRb, C 2-6 alkenyl, C2-6 alkynyl or C? 2-4 alkyyl substituted by C? 3-4 alkoxy or CF 3; R?4 is
Journal ArticleDOI
Substituent Effects on Edge‐to‐Face Aromatic Interactions
Fiona J. Carver,Christopher A. Hunter,David J. Livingstone,James F. McCabe,Eileen Mary Seward +4 more
TL;DR: Electrostatic interactions are responsible for the observed differences in interaction energy in hydrogen-bonded zipper complexes as a function of substituents on both aromatic rings.