E
Einar Solheim
Researcher at University of Bergen
Publications - 40
Citations - 2226
Einar Solheim is an academic researcher from University of Bergen. The author has contributed to research in topics: Metabolite & Antiestrogen. The author has an hindex of 22, co-authored 40 publications receiving 2123 citations.
Papers
More filters
Journal Article
Distribution of tamoxifen and its metabolites in rat and human tissues during steady-state treatment.
TL;DR: Significant amounts of drugs could be detected in lung, heart, ovary, and intestinal wall 14 months after withdrawal of tamoxifen, demonstrating efficient retention and slow washout of these compounds in human tissue.
Journal Article
Distribution of 4-Hydroxy-N-desmethyltamoxifen and Other Tamoxifen Metabolites in Human Biological Fluids during Tamoxifen Treatment
Ernst A. Lien,Einar Solheim,Oscar A. Lea,Steinar Lundgren,Stener Kvinnsland,Per Magne Ueland +5 more
TL;DR: Several metabolites of tamoxifen, including 4-hydroxylated, conjugated metabolites (Y, B, and BX), and N-desdimethyltamxifen (metabolite Z) were identified and their concentrations determined in fluids and feces from patients receiving chronic tamox ifen treatment, suggesting that the serum levels are production rate limited.
Journal ArticleDOI
Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients.
TL;DR: This is the first report on the distribution of tamoxifen and metabolites into human brain and brain tumour, and the data form a basis for further investigation into the therapeutic effects of tamxifen on brain metastases from breast cancer.
Journal ArticleDOI
Determinants of Cobalamin Status in Newborns
Anne-Lise Bjørke Monsen,Per Magne Ueland,Stein Emil Vollset,Anne Berit Guttormsen,Trond Markestad,Einar Solheim,Helga Refsum +6 more
TL;DR: A reduction in serum cobalamina and an increase in metabolite levels are consistent with impaired cobalamin function in a significant portion of the infants who were born to healthy, nonvegetarian mothers.
Journal ArticleDOI
Identification of organic eluates from four polymer‐based dental filling materials
TL;DR: The diversity of eluates from the four materials under study is demonstrated and, due to variation between the materials, the biocompatibility including the allergenic potential may be different.