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Elaine Wauthier
Researcher at University of North Carolina at Chapel Hill
Publications - 2
Citations - 1569
Elaine Wauthier is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Wnt signaling pathway & Progenitor cell. The author has an hindex of 2, co-authored 2 publications receiving 1457 citations.
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EpCAM-positive hepatocellular carcinoma cells are tumor initiating cells with stem/progenitor cell features
Taro Yamashita,Junfang Ji,Anuradha Budhu,Marshonna Forgues,Wen Yang,Hongyang Wang,Hu-Liang Jia,Qing-Hai Ye,Lun Xiu Qin,Elaine Wauthier,Lola M. Reid,Hiroshi Minato,Masao Honda,Shuichi Kaneko,Zhao-You Tang,Xin Wei Wang +15 more
TL;DR: The results suggest that HCC growth and invasiveness is dictated by a subset of EpCAM(+) cells, opening a new avenue for HCC cancer cell eradication by targeting Wnt/beta-catenin signaling components such as EpC AM.
Journal ArticleDOI
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM–positive hepatic cancer stem cells
Junfang Ji,Taro Yamashita,Anuradha Budhu,Marshonna Forgues,Hu Liang Jia,Cuiling Li,Chu-Xia Deng,Elaine Wauthier,Lola M. Reid,Qing Hai Ye,Lun Xiu Qin,Wen Yang,Hongyang Wang,Zhao-You Tang,Carlo M. Croce,Xin Wei Wang +15 more
TL;DR: The results define a novel regulatory link between miR‐181s and human EpCAM+ liver cancer stem/progenitor cells and imply that molecular targeting of miR-181 may eradicate HCC.