Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM–positive hepatic cancer stem cells
Junfang Ji,Taro Yamashita,Anuradha Budhu,Marshonna Forgues,Hu Liang Jia,Cuiling Li,Chu-Xia Deng,Elaine Wauthier,Lola M. Reid,Qing Hai Ye,Lun Xiu Qin,Wen Yang,Hongyang Wang,Zhao-You Tang,Carlo M. Croce,Xin Wei Wang +15 more
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TLDR
The results define a novel regulatory link between miR‐181s and human EpCAM+ liver cancer stem/progenitor cells and imply that molecular targeting of miR-181 may eradicate HCC.About:
This article is published in Hepatology.The article was published on 2009-08-01 and is currently open access. It has received 512 citations till now. The article focuses on the topics: Epithelial cell adhesion molecule & Cancer stem cell.read more
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miR-221 overexpression contributes to liver tumorigenesis
Pascal Pineau,Stefano Volinia,Katherine McJunkin,Agnès Marchio,Carlo Battiston,Benoit Terris,Vincenzo Mazzaferro,Scott W. Lowe,Carlo M. Croce,Anne Dejean +9 more
TL;DR: It is shown, using a mouse model of liver cancer, that miR-221 overexpression stimulates growth of tumorigenic murine hepatic progenitor cells, and DNA damage-inducible transcript 4 (DDIT4), a modulator of mTOR pathway, is identified as a bona fide target of miR -221.
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Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
TL;DR: In this paper, a review outlines pathogenic mechanisms that seem to be common to both hepatitis B virus and hepatitis C virus and suggest innovative approaches to the prevention and treatment of HCC.
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Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma
Jin Hou,Li Lin,Weiping Zhou,Zhengxin Wang,Guoshan Ding,Qiongzhu Dong,Lun-Xiu Qin,Xiaobing Wu,Yuanyuan Zheng,Yun Yang,Wei Tian,Qian Zhang,Chunmei Wang,Qinghua Zhang,Shi-Mei Zhuang,Limin Zheng,Anmin Liang,Wenzhao Tao,Xuetao Cao,Xuetao Cao +19 more
TL;DR: The third most highly expressed miR-199a/b-3p is consistently decreased in HCC, and its decrement significantly correlates with poor survival of HCC patients and contributes to better understanding of the important deregulated miRNAs in H CC and liver diseases.
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Mechanisms of HBV-induced hepatocellular carcinoma
TL;DR: HBV-related HCCs may arise on non-cirrhotic livers, further supporting the notion that HBV plays a direct role in liver transformation by triggering both common and etiology specific oncogenic pathways in addition to stimulating the host immune response and driving liver chronic necro-inflammation.
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Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier
Naoomi Tominaga,Nobuyoshi Kosaka,Makiko Ono,Takeshi Katsuda,Yusuke Yoshioka,Kenji Tamura,Jan Lötvall,Hitoshi Nakagama,Takahiro Ochiya +8 more
TL;DR: It is shown that cancer-derived extracellular vesicles, mediators of cell–cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB, and that systemic injection of brain metastatic cancer cell-derived EVs promoted brain metastasis of breast cancer cell lines and are preferentially incorporated into the brain in vivo.
References
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