Elan Cardozo Paes de Almeida

TL;DR: PC-L-D demonstrated great potential for further development as an anticancer drug and could be the key to developing more effective and less toxic therapies against oral cancer.

TL;DR: Among the 35 synthesized triazole naphthoquinones, compound 16 g was the most effective compound against OSCC cells, presenting high cytotoxicity, selectivity, and low acute toxicity on animals, and therefore might be considered for future cancer therapy.

TL;DR: Mechanistically, compound 4e promoted cell death by apoptosis in the OSCC cell, and molecular docking studies suggested this compound possibly targets enzymes important for tumor progression, such as RSK2, PKM2, and topoisomerase IIα.

TL;DR: In this article , the authors promote a multiple component reaction (MCR) among lawsone, arylaldehydes, and benzylamine to produce sixteen chemoselectively derived Mannich adducts of 1,4-naphthoquinones in good yield.

TL;DR: In this article , the authors evaluated the antiproliferative activity of E. hyemale and its partitions in oral squamous carcinoma cell lines, the death pathways induced by the most active partition, the acute toxicity and therapeutic activity, and the identification of the main compounds.