E
Elena C. McCoy
Researcher at New York Medical College
Publications - 21
Citations - 1731
Elena C. McCoy is an academic researcher from New York Medical College. The author has contributed to research in topics: Salmonella & Nitroreductase. The author has an hindex of 16, co-authored 21 publications receiving 1714 citations.
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The salmonella mutagenicity assay: Reproducibility
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Activation of a procarcinogen to a mutagen by cell-free extracts of anaerobic bacteria
TL;DR: Findings indicate that the Salmonella mutagenicity assay can be adapted to the study of the role of anaerobes in the activation of carcinogens.
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Non-mutagenic genotoxicants: Novobiocin and nalidixic acid, 2 inhibitors of DNA gyrase
TL;DR: The antimicrobial agents nalidixic acid and novobiocin preferentially inhibit the growth of DNA repair-deficient Escherichia coli, Salmonella typhimurium and Bacillus subtilis, but exhibit no demonstrable mutagenicity for S. typhimuium and E. coli even when tested under conditions designed to take the metabolic properties of these agents into consideration.
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Genetic activity of allyl chloride.
TL;DR: Allyl chloride (3-chloroprene) is mutagenic for Salmonella typhimurium and it induces gene conversions in Saccharomyces cerevisiae and it also displays DNA-modifying activity for E. coli.
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4-Nitroquinoline-1-oxide: factors determining its mutagenicity in bacteria.
TL;DR: Although reduction of the nitro group appears to be required for mutagenic activity, this reduction is not catalyzed by the nitroreductase required for the demonstration of the mutagenicity in bacteria of other nitro-containing mutagens (nitrofurans, 2-nitronaphthalene, nitrofluorenes).