Smoke and autoimmunity: The fire behind the disease.

Manifestaciones cutáneas atipícas en la sífilis

Atypical Cutaneous Manifestations in Syphilis

Tumours of the anal and perianal region are relatively rare, and clinically often interpreted as innocuous lesions, leading to frequent delays in diagnosis and adequate treatment. Although squamous cell neoplasia represents the most common entity encountered in this anatomically complex area, many conditions, both neoplastic and inflammatory, may occur. Adding to the challenge of correct diagnosis and patient management, recent years have seen major updates in the terminology of squamous cell neoplasia, created to reflect advances in our understanding of the role of human papilloma virus and unify previous terminologies used for different sites in the anogenital tract. However, squamous cell neoplasia in the anal canal and perianal region may differ in terms of histology, biological behaviour, staging and treatment. The aim of this review is to present an overview of neoplastic and non-neoplastic lesions that may be seen in this area, an update on important developments and terminology, potential pitfalls that may be encountered in routine pathology practice and a practical approach on how to resolve these issues.

https://jcp.bmj.com/content/jclinpath/68/12/971.full.pdf

Tumours and inflammatory lesions of the anal canal and perianal skin revisited: an update and practical approach

Malignant syphilis is an uncommon, but not unknown, ulcerative variation of secondary syphilis. The lesions typically begin as papules, which quickly evolve to pustules and then to ulcers with elevated edges and central necrosis. It is usually, but not mandatory, found in patients with some level of immunosuppression, such as HIV patients, when the TCD4+ cell count is >200 cells/mm3. Despite the anxiety the lesions cause, this form of the disease has a good prognosis. The general symptoms disappear right after the beginning of treatment, and lesions disappear over a variable period. This study reports the case of a 27-year-old man who has been HIV positive for 6 years, uses antiretroviral therapy incorrectly, has a TCD4+ cell count of 340 cells/mm3, a VDRL of 1:128 and itchy disseminated hyperchromic maculopapular lesions with rupioid crusts compatible with malignant syphilis.

Malignant syphilis in an AIDS patient

Malignant syphilis is a rare ulcerative variety. In the classical description of the disease, the absence of spirochetes in tissue samples was considered as a diagnostic criterion. We report 3 cases of malignant syphilis; in all of them, spirochetes were identified in cutaneous biopsy samples using immunohistochemical staining.

Pathologically confirmed malignant syphilis using immunohistochemical staining: report of 3 cases and review of the literature.

Auteur(s) : Cristina GOMEZ-FERNANDEZ1 crisgomezfernandez@hotmail.com, Pedro HERRANZ PINTO1, Beatriz CASADO VERRIER1, Elena SENDAGORTA CUDOS1, Maria Jose BEATO-MERINO2, Mariano CASADO JIMENEZ1 1 University Hospital La Paz, Department of Dermatology, Paseo de la Castellana, 261, 28046. Madrid, Spain 2 University Hospital La Paz, Department of Pathology, Madrid, Spain Bupropion hydrochloride is a psychotropic drug with significant antidepressant effects through the inhibition of re-uptake of norepinephrine [...]

Drug eruption and exacerbation of psoriasis related to bupropion

http://www.jaad.org/article/S019096222202970X/pdf

Elena Sendagorta Cudós

Papers

Pathologically confirmed malignant syphilis using immunohistochemical staining: report of 3 cases and review of the literature.

Drug eruption and exacerbation of psoriasis related to bupropion

Human monkeypox outbreak: Epidemiological data and therapeutic potential of topical cidofovir in a prospective cohort study

Diagnóstico y tratamientoEritema nudosoErythema nodosum

[Sexually Transmitted Infections During the First Wave of the COVID-19 Pandemic in Spain].