E
Eli Gilboa
Researcher at University of Miami
Publications - 199
Citations - 25400
Eli Gilboa is an academic researcher from University of Miami. The author has contributed to research in topics: Immunotherapy & Antigen. The author has an hindex of 82, co-authored 197 publications receiving 24328 citations. Previous affiliations of Eli Gilboa include Hebrew University of Jerusalem & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
Jens Dannull,Zhen Su,David A. Rizzieri,Benjamin K. Yang,Doris Coleman,Donna Yancey,Aijing Zhang,Philipp Dahm,Nelson J. Chao,Eli Gilboa,Johannes Vieweg +10 more
TL;DR: It is shown that DAB(389)IL-2 is capable of selectively eliminating CD25-expressing Tregs from the PBMCs of cancer patients without inducing toxicity on other cellular subsets with intermediate or low expression of CD25.
Journal ArticleDOI
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras.
James O. McNamara,Eran R. Andrechek,Yong Wang,Kristi D. Viles,Rachel E. Rempel,Eli Gilboa,Bruce A. Sullenger,Paloma H. Giangrande +7 more
TL;DR: A aptamer-siRNA chimeric RNAs capable of cell type–specific binding and delivery of functional siRNAs into cells and specifically inhibit tumor growth and mediate tumor regression in a xenograft model of prostate cancer.
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Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.
TL;DR: The finding that RNA transcribed in vitro from cDNA cloned in a bacterial plasmid was highly effective in sensitizing DC shows that amplification of the antigenic content from a small number of tumor cells is feasible, thus expanding the potential use of RNA-pulsed DC- based vaccines for patients bearing very small, possibly microscopic, tumors.
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Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.
TL;DR: Two studies highlight the potential advantages of localized secretion of cytokines mediated via gene transfer to induce potent anti-tumor immune responses and co-injection of IL-2- producing CMS-5 cells with unmodified tumor cells inhibited tumor formation.
Tumor Cells Abrogates Tumorigenicity and Induces Protective Immunity
TL;DR: In this article, the effects of localized secretion of cytokines mediated via gene transfer to induce potent anti-tumor immune responses were studied in a mouse fibrosarcoma cell line of BALB/c origin.