E
Elina I. Nagaeva
Researcher at University of Helsinki
Publications - 13
Citations - 146
Elina I. Nagaeva is an academic researcher from University of Helsinki. The author has contributed to research in topics: Ventral tegmental area & Dopaminergic. The author has an hindex of 6, co-authored 10 publications receiving 104 citations. Previous affiliations of Elina I. Nagaeva include I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry & Russian Academy of Sciences.
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Journal ArticleDOI
Inhibition of the NMDA and AMPA Receptor Channels by Antidepressants and Antipsychotics
Oleg I. Barygin,Elina I. Nagaeva,Denis B. Tikhonov,Darya A. Belinskaya,Nina P. Vanchakova,Natalia N. Shestakova +5 more
TL;DR: Action of fluoxetine and clozapine was found to be voltage- and magnesium-independent, and all voltage-dependent compounds could be trapped in closed NMDA receptor channels.
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Monoamine NMDA receptor channel blockers inhibit and potentiate native and recombinant proton-gated ion channels.
Tatiana B. Tikhonova,Elina I. Nagaeva,Oleg I. Barygin,Natalia N. Potapieva,K. V. Bolshakov,Denis B. Tikhonov +5 more
TL;DR: The results demonstrate that, depending on the subunit composition, ASICs can be activated or inhibited by simple compounds that possess only amino group and aromatic/hydrophobic moieties, which opens up the possibility to search for new ASIC modulators among a number of endogenous ligands.
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Histamine selectively potentiates acid-sensing ion channel 1a.
TL;DR: It is proposed that histamine and possibly some other endogenous amines can positively modulate ASICs functions and enhance their responses to physiologically significant level.
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Determinants of action of hydrophobic amines on ASIC1a and ASIC2a.
Elina I. Nagaeva,Natalia N. Potapieva,Maxim V. Nikolaev,V. E. Gmiro,Lev G. Magazanik,Denis B. Tikhonov +5 more
TL;DR: The results suggest that hydrophobic amines cause complex action on ASICs, and found that the most active compounds are monocations with protonatable aminogroup.
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Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites
TL;DR: A systematic view of the complex pattern of interactions between ligands and ASIC1a is presented, which includes inorganic cations, a large number of synthetic and endogenous small molecules, and peptide toxins.