Showing papers by "Elisabetta Meucci published in 2013"
TL;DR: The role of thyroid hormones in regulation of antioxidant systems is reviewed, also presenting data on total antioxidant capacity and Coenzyme Q10, and published studies suggest that oxidative stress could be involved in the clinical course of different heart diseases.
Abstract: In previous works we demonstrated an inverse correlation between plasma Coenzyme Q10 (CoQ10) and thyroid hormones; in fact, CoQ10 levels in hyperthyroid patients were found among the lowest detected in human diseases. On the contrary, CoQ10 is elevated in hypothyroid subjects, also in subclinical conditions, suggesting the usefulness of this index in assessing metabolic status in thyroid disorders. A Low-T3 syndrome is a condition observed in several chronic diseases: it is considered an adaptation mechanism, where there is a reduction in pro-hormone T4 conversion. Low T3-Syndrome is not usually considered to be corrected with replacement therapy. We review the role of thyroid hormones in regulation of antioxidant systems, also presenting data on total antioxidant capacity and Coenzyme Q10. Published studies suggest that oxidative stress could be involved in the clinical course of different heart diseases; our data could support the rationale of replacement therapy in low-T3 conditions.
32 citations
TL;DR: It is suggested, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants through modulation of antioxidant systems.
Abstract: Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants
17 citations
TL;DR: Treatment with testosterone, both in intramuscular or bioadhesive buccal formulations, is shown to increase plasma levels of Coenzyme Q10, lipophilic antioxidant, and total antioxidant capacity, measured with colorimetric method, in patients with secondary hypogonadism.
Abstract: From cross-sectional studies in healthy men, lower plasma total testosterone levels seem to be associated with hyperinsulinemia, decreased glucose tolerance, and a higher level of cardiovascular risk factors. Despite in vitro and in vivo experiments suggest a key role of testosterone in modulating antioxidant systems in different tissues, few data are reported in humans. Extending our previous results, we show that treatment with testosterone, both in intramuscular or bioadhesive buccal formulations, increase plasma levels of Coenzyme Q10, lipophilic antioxidant, and total antioxidant capacity, measured with colorimetric method, in patients with secondary hypogonadism. Hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk in such patients.