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Elizabeth L. Castle
Researcher at Dalhousie University
Publications - 10
Citations - 48
Elizabeth L. Castle is an academic researcher from Dalhousie University. The author has contributed to research in topics: Autophagy & RHOA. The author has an hindex of 2, co-authored 9 publications receiving 17 citations. Previous affiliations of Elizabeth L. Castle include University of British Columbia.
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Journal ArticleDOI
Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells.
Kathleen M. Attwood,Aaron Robichaud,Lauren P Westhaver,Elizabeth L. Castle,David M. Brandman,Aruna D. Balgi,Michel Roberge,Patricia Colp,Sidney E Croul,Inhwa Kim,Craig McCormick,Jennifer A. Corcoran,Adrienne Weeks +12 more
TL;DR: Findings indicate that modulating the stress response can be used to exploit the hypoxic niche of GBM tumors, causing cell death by disrupting pro-survival stress responses and control of protein synthesis.
Posted ContentDOI
Human coronaviruses disassemble processing bodies
Carolyn-Ann Robinson,Mariel Kleer,Rory P. Mulloy,Rory P. Mulloy,Elizabeth L. Castle,Bre Q. Boudreau,Jennifer A. Corcoran,Jennifer A. Corcoran +7 more
TL;DR: Exposure to SARS-CoV-2 and the common cold hu CoVs, OC43 and 229E, induced PB loss is shown to contribute to enhanced proinflammatory cytokine production observed during severe Sars-Cov-2 infection.
Posted ContentDOI
Viral manipulation of a novel mechanoresponsive signaling axis disassembles processing bodies
Elizabeth L. Castle,Pauline Douglas,Kristina D. Rinker,Jennifer A. Corcoran,Jennifer A. Corcoran +4 more
TL;DR: It is demonstrated that processing bodies (PBs), cytoplasmic sites of RNA decay, are regulated by mechanical signaling events that alter actin dynamics, and implies that cytoskeletal changes in other pathologies may similarly impact the inflammatory environment.
Journal ArticleDOI
Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies.
Elizabeth L. Castle,Carolyn-Ann Robinson,Pauline Douglas,Kristina D. Rinker,Jennifer A. Corcoran,Jennifer A. Corcoran +5 more
TL;DR: In this paper, Kaposi's sarcoma-associated herpesvirus is the etiological agent of the inflammatory endothelial cancer, Kaposi’s Sarcoma, and a PB-regulating virus.
Posted ContentDOI
A viral protein utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies
Carolyn-Ann Robinson,Carolyn-Ann Robinson,Gillian K. Singh,Elizabeth L. Castle,Bre Q. Boudreau,Jennifer A. Corcoran,Jennifer A. Corcoran +6 more
TL;DR: In this article, the Kaposi9s sarcoma-associated herpesvirus (KSHV) KapB protein increases the synthesis of inflammatory mediators by driving autophagy and triggering PB disassembly.