E
Elizabeth L. Dunphy
Researcher at University of Washington
Publications - 4
Citations - 266
Elizabeth L. Dunphy is an academic researcher from University of Washington. The author has contributed to research in topics: Histone acetyltransferase activity & Protein subunit. The author has an hindex of 4, co-authored 4 publications receiving 256 citations.
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Journal ArticleDOI
Deletion of Type IIα Regulatory Subunit Delocalizes Protein Kinase A in Mouse Sperm without Affecting Motility or Fertilization
Kimberly A. Burton,Barbara Treash-Osio,Charles H. Muller,Elizabeth L. Dunphy,G. Stanley McKnight +4 more
TL;DR: It is demonstrated that the highly localized pattern of PKA seen in mature sperm is not essential for motility or fertilization.
Journal ArticleDOI
Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression.
TL;DR: It is demonstrated that the ability of the ts13 allele of TAFII250 to acetylate histones in vitro is temperature sensitive suggesting that this enzymatic activity is compromised at 39.5°C, which suggests that TAF II250 acetyltransferase activity is required for cell cycle progression and regulates the expression of essential proliferative control genes.
Journal ArticleDOI
TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.
TL;DR: It is hypothesized that TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G1-to-S-phase progression.
Journal ArticleDOI
Expression of the casein kinase 2 subunits in Chinese hamster ovary and 3T3 L1 cells provides information on the role of the enzyme in cell proliferation and the cell cycle.
Dongxia Li,Grażyna Dobrowolska,Lauri D. Aicher,Mingzi Chen,Jocelyn H. Wright,Peter Drueckes,Elizabeth L. Dunphy,Erlynda Munar,Edwin G. Krebs +8 more
TL;DR: Results from both transient and stable expression of CK2 subunits strongly suggest that CK2 may be involved in the control of cell growth and progression of the cell cycle.