Elizabeth S. Henson

TL;DR: A novel induction of ferroptosis through altered iron regulation is indicated by treating breast cancer cells with a lysosome disruptor and a tyrosine kinase inhibitor and the expression of transferrin is increased and ferroportin-1 is decreased.

TL;DR: This work shows that autophagic cell death is induced by hypoxia in cancer cells with intact apoptotic machinery, and it can also function as a mechanism of programmed cell death.

TL;DR: The EGF survival signaling network is discussed, how it cross-talks with the apoptotic signaling pathways and the therapeutic drugs targeting the E GF survival pathway used to treat cancers are discussed.

TL;DR: It is found that intracellular iron level increased in a time dependent manner following treatment accompanied by an increase in ROS, which indicates that ferroptosis and autophagy induced cell death occur independently but both are mediated by iron dependent ROS generation in breast cancer cells.

TL;DR: It is demonstrated that the epidermal growth factor stimulation of human embryonic kidney cells HEK 293 and breast cancer cell line MDA MB 231 effectively protects these cells from TRAIL-induced apoptosis in a dose-dependent manner and indicates that EGF receptor activation provides a survival response against TRAIL's apoptosis.