Elizabeth Swann

TL;DR: In this paper, a series of functionalised benzophenoxazinones, analogues of Nile Red, is prepared and their fluorescence properties evaluated. The ring system is prepared by reaction of============5-diethylamino-2-nitrosophenol with 1,6-dihydroxynaphthalene============Initiation of 2-hydroxy group with======6-bromohexanoic acid derivatives.

TL;DR: A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) revealed that compounds with electron-withdrawing groups at the indole 3-position were among the best substrates, whereas those with amine groups atThe 5- position were poor substrates.

TL;DR: ES936 abrogates the toxicity of streptonigrin, with greater effects seen in cell lines expressing higher levels of NQO1, and does not inhibit other cellular reductases, nor does it alter cellular levels of acid-soluble thiols.

TL;DR: A modified version of the Bischler indole synthesis has been developed in which the key step is the N-H insertion reaction of rhodium carbene intermediates derived from α-diazo-β-ketoesters with anilines as mentioned in this paper.

TL;DR: The synthesis of the indolequinones 8 and 9 starting from methyl 4-(benzyloxy)-5-methoxy-indole-2-carboxylate (10) is described, with many of the compounds in each series showing greater toxicity toward hypoxic cells.