Els Van Der Schueren

TL;DR: It is concluded that KRP2 exerts a plant growth inhibitory activity by reducing cell proliferation in leaves, but, in contrast to its mammalian counterparts, it may not control the timing of cell cycle exit and differentiation.

TL;DR: It is argued that controlled exit of the cell cycle is a prerequisite for normal plant development because E2Fa–DPa transgenic plants arrested early in development.

TL;DR: It is concluded that the plant WEE1 gene is not rate-limiting for cycle progression under normal growth conditions but is a critical target of the ATR-ATM signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints, coupling mitosis to DNA repair in cells that suffer DNA damage.

TL;DR: Surprisingly, CDKB1;1 transcription was controlled by the E2F pathway, as shown by its upregulation in E2Fa-DPa–overproducing plants and mutational analysis of the E1-S and G2-M binding site in the CDKB 1;1 promoter.

TL;DR: It is shown that the A-type cyclin-dependent kinase CDKA;1 and its specific inhibitor, the Kip-related protein, KRP2 regulate the mitosis-to-endocycle transition during Arabidopsis thaliana leaf development and illustrated that K RP2 protein abundance is regulated posttranscriptionally through CDK phosphorylation and proteasomal degradation.