Emad S. Alnemri

TL;DR: A cell permeable Bcl-2 binding peptide, cpm-1285, was designed by chemically attaching a fatty acid to a peptide derived from the proapoptotic protein Bad and had in vivo activity in slowing human myeloid leukemia growth in severe combined immunodeficient mice.

TL;DR: The data suggest that Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could play a role in the regulation of IL-1β secretion and NF-κB activation during the pro-inflammatory cytokine response.

TL;DR: A role for calpain in the early phases of the radiation-induced apoptosis pathway, upstream of the caspases is supported, as was the calpain-mediated hydrolysis of casein in the Burkitts' Lymphoma cell line BL30A.

TL;DR: Findings suggest that ERK1-mediated posttranslational modifications license the NLRP3 inflammasome to respond to the second signal ATP by inducing post translational events that are independent of new production of pro–IL-1β and NOD-like receptor components.

TL;DR: Gel filtration analysis of the IKK complex revealed that TNFα stimulation induces a large increase in the size of this complex, suggesting oligomerization, and data suggest that IKKγ functions as a signaling adaptor between the upstream regulators such as RIP and the Ikks and that oligomersization of theIKK complex by upstream regulators is a critical step in activation of thiscomplex.