다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and is one of the leading causes of mortality. The cases reported and the predictions for the near future are unthinkable. Food and Drug Administration data showed that 40% of the approved molecules are natural compounds or inspired by them, from which, 74% are used in anticancer therapy. In fact, natural products are viewed as more biologically friendly, that is less toxic to normal cells. In this review, the most recent and successful cases of secondary metabolites, including alkaloid, diterpene, triterpene and polyphenolic type compounds, with great anticancer potential are discussed. Focusing on the ones that are in clinical trial development or already used in anticancer therapy, therefore successful cases such as paclitaxel and homoharringtonine (in clinical use), curcumin and ingenol mebutate (in clinical trials) will be addressed. Each compound's natural source, the most important steps in their discovery, their therapeutic targets, as well as the main structural modifications that can improve anticancer properties will be discussed in order to show the role of plants as a source of effective and safe anticancer drugs.

https://www.mdpi.com/1422-0067/19/1/263/pdf

Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application.

Cancer is a serious concern at present. A large number of patients die each year due to cancer illnesses in spite of several interventions available. Development of an effective and side effects lacking anticancer therapy is the trending research direction in healthcare pharmacy. Chemical entities present in plants proved to be very potential in this regard. Bioactive phytochemicals are preferential as they pretend differentially on cancer cells only, without altering normal cells. Carcinogenesis is a complex process and includes multiple signaling events. Phytochemicals are pleiotropic in their function and target these events in multiple manners; hence they are most suitable candidate for anticancer drug development. Efforts are in progress to develop lead candidates from phytochemicals those can block or retard the growth of cancer without any side effect. Several phytochemicals manifest anticancer function in vitro and in vivo. This article deals with these lead phytomolecules with their action mechanisms on nuclear and cellular factors involved in carcinogenesis. Additionally, druggability parameters and clinical development of anticancer phytomolecules have also been discussed.

/pdf/lead-phytochemicals-for-anticancer-drug-development-2tw3uui46a.pdf

Lead Phytochemicals for Anticancer Drug Development.

modern magnetic materials principles and applications is available in our book collection an online access to it is set as public so you can download it instantly. Our book servers hosts in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the modern magnetic materials principles and applications is universally compatible with any devices to read.

Modern Magnetic Materials Principles And Applications

Blood pressure measurement

Background 
Prostate cancer (PCa) is rated the second most common cancer and sixth leading cause of cancer deaths among men globally. Reports show that African men suffer disproportionately from PCa compared to men from other parts of the world. It is still quite difficult to accurately describe the burden of PCa in Africa due to poor cancer registration systems. We systematically reviewed the literature on prostate cancer in Africa and provided a continent-wide incidence rate of PCa based on available data in the region.


Methods 
A systematic literature search of Medline, EMBASE and Global Health from January 1980 to June 2015 was conducted, with additional search of Google Scholar, International Association of Cancer Registries (IACR), International Agency for Research on Cancer (IARC), and WHO African region websites, for studies that estimated incidence rate of PCa in any African location. Having assessed quality and consistency across selected studies, we extracted incidence rates of PCa and conducted a random effects meta-analysis.


Results 
Our search returned 9766 records, with 40 studies spreading across 16 African countries meeting our selection criteria. We estimated a pooled PCa incidence rate of 22.0 (95% CI: 19.93–23.97) per 100,000 population, and also reported a median incidence rate of 19.5 per 100,000 population. We observed an increasing trend in PCa incidence with advancing age, and over the main years covered.


Conclusion 
Effective cancer registration and extensive research are vital to appropriately quantifying PCa burden in Africa. We hope our findings may further assist at identifying relevant gaps, and contribute to improving knowledge, research, and interventions targeted at prostate cancer in Africa.

/pdf/an-estimate-of-the-incidence-of-prostate-cancer-in-africa-a-ovjhp3akmj.pdf

An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis

Proximate analysis of the seeds of Brachystegia eurycoma and Detrarium microcarpum were carried out on both the dehulled and undehulled samples of the flour. The protein content of the seeds are quite low 9.1;7.2 and 11.4;8.2 for undehulled and dehulled Brachystegia eurycoma and Detarium microcarpum, respectively. Crude fibre is less than 3% in each, while ash was less than 5% each per 100gm dry weight of sample. Detarium microcarpum has a higher crude fat composition 18.5±0.03, 15.5±0.02 while Brachystegia eurycoma 15.5±0.04, 14.0±0.01 for the undehulled and dehulled samples respectively. Moisture content is higher in dehulled samples 14.3±0.01 and 16.7±0.03 for both seed types. The available carbohydrate is equally higher in the dehulled samples 59.0±0.01 and 57.0±0.01, respectively for both seeds. The sodium, potassium, calcium and magnesium contents were less than 1% each, with calcium having the highest concentration, followed by phosphorous. The phytochemical analysis showed the presence of alkaloids, tannins, saponins and flavonoids. Brachystegia eurcoma showed no presence of tannin. The findings are of nutritional relevance since these seeds are used for soup thickening by many homes in the southeastern Nigeria.

/pdf/effect-of-processing-methods-on-nutritive-and-antinutritive-4hcpnyt3c6.pdf

Effect of Processing Methods on Nutritive and Antinutritive Properties of Seeds of Brachystegia eurycoma and Detarium microcarpum from Nigeria

Background: Maternal mortality and morbidity reflect the status of population health and quality of life across nations. Poor understanding of the interplay of many antecedent factors, including sociocultural, economic and logistic factors, combined with an overwhelming poor health services delivery, is a basic challenge in several countries, particularly in rural settings where functional health care services are relatively scarce. There are still uncertainties as to the extent of this burden, owing to current challenges with information and data collation. This study aimed at identifying nonmedical factors associated with maternal mortality in rural and semiurban communities of southwestern Nigeria.
Methodology: The study was carried out in Ado-Odo/Ota Local Government Area of Ogun State. A multistage sampling technique and an informant survey approach were used in the study. A total sample of 360 eligible respondents were selected randomly from 11 out of 16 political wards in the study area and interviewed through the administration of questionnaires. The data were processed using descriptive statistics and regression analyses.
Results: Place of consultation (P=0.000), who pays the treatment costs (P=0.000), awareness of pregnancy complications (P=0.002) and knowledge of the place of antenatal care treatment (P=0.000) significantly influenced maternal mortality (proxy by place of delivery of last birth). The F-statistic (15.100) confirmed the hypothesis that nonmedical factors influence maternal mortality. The correlation of predictor variables was significant at both the 0.01 level and the 0.05 level (2-tailed).
Conclusion: Our findings suggest that in a rural community setting with a depleted health care system, health education tailored toward community culture, subsidized maternal health care services by the government and operators of private clinics, as well as empowering and improving the status of women may reduce maternal mortality and prompt better utilization and survival chances of women in the study area as well as in all of Nigeria.

/pdf/factors-influencing-maternal-mortality-among-rural-476k422j1e.pdf

Factors influencing maternal mortality among rural communities in southwestern Nigeria.

/pdf/comparative-effects-of-local-coagulants-on-the-nutritive-1py2d7knzl.pdf

Comparative effects of local coagulants on the nutritive value, in vitro multienzyme protein digestibility and sensory properties of Wara cheese.

This study was designed to screen different extracts of 15 commonly consumed Nigerian food
plants for anti-cancer and free radical scavenging activities. Leaves, seeds or fruits of the plants
were each successively extracted with n-hexane, dichloromethane, ethanol and water. The cytotoxic
activity of each of the extracts was tested against human myeloid leukemia (HL-60), human
hepatocellular carcinoma (SMMC-7721), human lung carcinoma (A-549), human breast
adenocarcinoma (MCF-7) and colon cancer (SW480) cell lines using Cisplatin as standard. The free
radical scavenging activities of the extracts against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were also
determined. The dichloromethane extract of Vernonia amygdalina leaves (VA-D) showed the
strongest cytotoxic activity against all the cancer cell lines with IC50 range of 5.85-8.84 pg mL - 1 The
dichloromethane extract of Gongronema latifolium leaves (GL-D) showed the highest activity
against A-549 and MCF-7 with IC50 of 9.57 and 6.51 pg mL -l, respectively, while Piper guineense
leaves (PG-D) exhibited the highest activity against HL-60 with IC50 of 3.62 pg mL - 1 The other
extracts were inactive against the cancer cell lines. The ethanolic extract of Sesamum indicum
leaves (81-E) and Mucuna pruriens seeds (MP-E) showed the highest free radical scavenging
activity with SC50 of 6.8 and 7.3xl0-2 mg mL -l, respectively. Other extracts of some of the food plant
samples showed varying free radical scavenging activities. The results from this study suggest that
some of the food plants screened may possess anti -cancer and antioxidant properties.

Emeka E. J. Iweala

Papers

An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis

Effect of Processing Methods on Nutritive and Antinutritive Properties of Seeds of Brachystegia eurycoma and Detarium microcarpum from Nigeria

Factors influencing maternal mortality among rural communities in southwestern Nigeria.

Comparative effects of local coagulants on the nutritive value, in vitro multienzyme protein digestibility and sensory properties of Wara cheese.

Anti-Cancer and Free Radical Scavenging Activity of Some Nigerian Food Plants In vitro.