Emilie Werbrouck

TL;DR: Despite significant research efforts, including translational efforts and new imaging techniques, no predictive biomarkers have been clinically validated and therefore a more refined approach to treatment tailoring remains beyond the authors' reach.

TL;DR: The diagnostic accuracy of oesophageal biopsies alone in predicting final pathology in Barrett's dysplasia is only 61%, and the majority of upgraded lesions are detectable.

TL;DR: Hypogonadism is a frequent finding in male mRCC-patients at start of targeted therapies and in contrast to pazopanib, during sunitinib therapy, TT- and LH-levels tend to decrease, leading to an increased incidence of secondary hypogonADism.

TL;DR: The case demonstrates the importance of considering tumoral bleeding as a side effect of BRAF and MEK inhibition in responding melanoma patients and suggests Mechanical intervention can be effective in resolving this treatment-related adverse event.

TL;DR: Polymorphism rs2231142 in the efflux pump ABCG2 is associated with hypothyroidism in mRCC patients treated with sunitinib, and significant associations were found between PDGFRA rs35597368 and rs1800812 and time-to-TSH- increase at day 28.