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Brigitte Decallonne
Researcher at Katholieke Universiteit Leuven
Publications - 120
Citations - 5683
Brigitte Decallonne is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 31, co-authored 99 publications receiving 5038 citations. Previous affiliations of Brigitte Decallonne include Catholic University of Leuven & The Catholic University of America.
Papers
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Journal ArticleDOI
An overview of real-time quantitative PCR: applications to quantify cytokine gene expression.
Annapaula Giulietti,Lutgart Overbergh,Dirk Valckx,Brigitte Decallonne,Roger Bouillon,Chantal Mathieu +5 more
TL;DR: The real-time RT-PCR technique is very accurate and sensitive, allows a high throughput, and can be performed on very small samples; therefore it is the method of choice for quantification of cytokine profiles in immune cells or inflamed tissues.
Journal Article
The Use of Real-Time Reverse Transcriptase PCR for the Quantification of Cytokine Gene Expression
Lutgart Overbergh,Annapaula Giulietti,Dirk Valckx,Brigitte Decallonne,Roger Bouillon,Chantal Mathieu +5 more
TL;DR: The development of real-time RT-PCR has resulted in an exponential increase in its use over the last couple of years, and the method has undoubtedly become the standard for quantifying cytokine patterns, clarifying many functional properties of immune cells and their associated diseases.
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High doses of vitamin D to reduce exacerbations in chronic obstructive pulmonary disease: a randomized trial.
An Lehouck,Chantal Mathieu,Claudia Carremans,Femke Baeke,Jan Verhaegen,Johan Van Eldere,Brigitte Decallonne,Roger Bouillon,Marc Decramer,Wim Janssens +9 more
TL;DR: In this article, the authors explored whether supplementing with high doses of vitamin D could reduce the incidence of COPD exacerbations and found that the effect of high-dose vitamin D supplements may extend beyond preventing osteoporosis.
Journal ArticleDOI
Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages.
Lutgart Overbergh,Brigitte Decallonne,Dirk Valckx,Annemieke Verstuyf,Jos Depovere,Jozef Laureys,Omer Rutgeerts,Rene Saint-Arnaud,Roger Bouillon,Chantal Mathieu +9 more
TL;DR: It is proposed that the up‐regulation of 1‐α‐hydroxylase in activated macrophages, resulting in the synthesis of 1,25(OH)2D3, might be a negative feedback loop in inflammation.
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Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice
Annapaula Giulietti,Conny Gysemans,Katinka Stoffels,E. van Etten,Brigitte Decallonne,Lut Overbergh,Roger Bouillon,Chantal Mathieu +7 more
TL;DR: The data in NOD mice, as well as human epidemiological data, point to the importance of preventing vitamin D deficiency in early childhood, and controlling this dietary factor could be an easy and safe way to reduce the incidence of Type 1 diabetes in subjects who are genetically at risk.