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Emmanuel N Kontomanolis
Researcher at Democritus University of Thrace
Publications - 59
Citations - 904
Emmanuel N Kontomanolis is an academic researcher from Democritus University of Thrace. The author has contributed to research in topics: Pregnancy & Cancer. The author has an hindex of 13, co-authored 44 publications receiving 607 citations.
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Journal ArticleDOI
Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review.
Emmanuel N Kontomanolis,Antonios Koutras,Athanasios Syllaios,Dimitrios Schizas,Aikaterini Mastoraki,Nikolaos Garmpis,Michail Diakosavvas,Kyveli Angelou,Georgios Tsatsaris,Athanasios Pagkalos,Thomas Ntounis,Zacharias Fasoulakis +11 more
TL;DR: The evidence that neoplasm develop as the after-effect of the increase of acquired and physical genetic variations in proto-oncogenes and tumor-suppressor genes is highlighted; these form a target group in the cells of neoplasms.
Journal ArticleDOI
Serum and Tissue LDH Levels in Patients with Breast/Gynaecological Cancer and Benign Diseases
Michael I. Koukourakis,Emmanuel N Kontomanolis,Alexandra Giatromanolaki,Efthimios Sivridis,V. Liberis +4 more
TL;DR: Serum and tissue LDH is up-regulated in gynaecologic and breast malignancies and in a subset of benign conditions such as fibro- and cystadenomas.
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Vascular endothelial growth factor gene polymorphisms and pre‐eclampsia
Dimitrios Papazoglou,Georgios Galazios,Michael I. Koukourakis,Ioannis Panagopoulos,Emmanuel N Kontomanolis,Konstantinos Papatheodorou,Efstratios Maltezos +6 more
TL;DR: The VEGF gene polymorphisms studied are unlikely to be major predisposing factors for pre-eclampsia, and the presence of the 936T allele probably has a considerable effect on disease modification.
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The Notch Pathway in Breast Cancer Progression
Emmanuel N Kontomanolis,Sofia Kalagasidou,Stamatia Pouliliou,Xanthoula Anthoulaki,Nikolaos Georgiou,Valentinos Papamanolis,Zacharias Fasoulakis +6 more
TL;DR: Current data prove that Notch pathway has a major participation and multiple roles during breast tumor progression and inhibition of Notch receptors and ligands provides innovative therapeutic results and could become the therapy of choice in the next few years, even though further research is needed to reach safe conclusions.
Journal ArticleDOI
Association of −634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm delivery
Dimitrios Papazoglou,Georgios Galazios,Michael I. Koukourakis,Emmanuel N Kontomanolis,Efstratios Maltezos +4 more
TL;DR: The present study was undertaken to examine the possible relationship between two common functional VEGF gene polymorphisms, linked with altered V EGF gene responsiveness, and spontaneous preterm delivery.