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Ioannis Panagopoulos
Researcher at Oslo University Hospital
Publications - 282
Citations - 9622
Ioannis Panagopoulos is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Fusion gene & Medicine. The author has an hindex of 55, co-authored 223 publications receiving 8499 citations. Previous affiliations of Ioannis Panagopoulos include Lund University & Stockholm University.
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Journal Article
Fusion of the EWS and CHOP genes in myxoid liposarcoma.
Ioannis Panagopoulos,Mattias Höglund,Fredrik Mertens,Nils Mandahl,Felix Mitelman,Pierre Åman +5 more
TL;DR: The translocation t(12;16)(q13;p11) which cytogenetically characterizes myxoid liposarcomas (MLS) results in a fusion of the CHOP gene in 12q13 and the FUS gene in 16p11, creating a chimeric FUS/CHOP gene as discussed by the authors.
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Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.
Fredrik Mertens,Christopher D.M. Fletcher,Cristina R. Antonescu,Jean-Michel Coindre,Maurizio Colecchia,Henryk A. Domanski,Erinn Downs-Kelly,Cyril Fisher,John R. Goldblum,Louis Guillou,Robin Reid,Juan Rosai,Raphael Sciot,Nils Mandahl,Ioannis Panagopoulos +14 more
TL;DR: Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant F US/CREb3L1 fusion.
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Fusion of the EWS and CHOP genes in myxoid liposarcoma
Ioannis Panagopoulos,Mattias Höglund,Fredrik Mertens,Nils Mandahl,Felix Mitelman,Pierre Åman +5 more
TL;DR: The presence of the EWS/CHOP chimeric gene in MLS shows that the N-terminal part of FUS may be replaced by the N of EWS in a CHOP fusion oncoprotein, and the tumorigenic process in MLS and the morphogenetically distinctly different EWS-associated tumor types may be related.
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Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma.
TL;DR: The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS.
Journal ArticleDOI
Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
Ioannis Panagopoulos,Thoas Fioretos,Margareth Isaksson,Ulf Samuelsson,Rolf Billström,Bodil Strömbeck,Felix Mitelman,Bertil Johansson +7 more
TL;DR: It is shown here that a novel t(10;16)(q22;p13) in a childhood AML M5a leads to a MORF-CBP chimera, and their exact role in the leukemogenic process remains to be elucidated.