Engin Kendi

TL;DR: A novel series of 1-thiocarbamoyl-3-substituted phenyl-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole derivatives as promising MAO-B inhibitors was synthesized and investigated for the ability to inhibit selectively the activity of the A and B isoforms of monoamine oxidation.

TL;DR: A new series of pyrazoline derivatives were prepared starting from a quinazolinone ring and evaluated for antidepressant, anxiogenic and MAO-A and -B inhibitory activities by in vivo and in vitro tests, respectively, and it appears that the binding interactions for this class of compounds are mostly hydrophobic.

TL;DR: 2, 3, 4 and 5 were evaluated for their potentiating effects on pentobarbital induced hypnosis and most of the compounds caused remarkable increases in pentobarBital sleeping time.

TL;DR: Most of the compounds exhibited both anticonvulsant and antimicrobial activities; the O-alkyl substituted compounds (2, 3, 4 and 5) were found to be more active than theO-arylalkyl substitution compounds in both screening paradigms.

TL;DR: In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives (Va-f and VIa-f) were synthesized and evaluated for their antibacterial and antifungal activities against Staphylococcus a Aureus, methicillin resistant S. aureus, and Escherichia coli.