E
Eric B. Holub
Researcher at University of Warwick
Publications - 87
Citations - 9989
Eric B. Holub is an academic researcher from University of Warwick. The author has contributed to research in topics: Arabidopsis & Gene. The author has an hindex of 47, co-authored 87 publications receiving 9184 citations. Previous affiliations of Eric B. Holub include Norwich Research Park & University of Chicago.
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Journal ArticleDOI
Different Requirements for EDS1 and NDR1 by Disease Resistance Genes Define at Least Two R Gene-Mediated Signaling Pathways in Arabidopsis
Nicole Aarts,Matthew Metz,Eric B. Holub,Brian J. Staskawicz,Michael J. Daniels,Jane E. Parker +5 more
TL;DR: The results provide compelling evidence for the preferential utilization of either signaling component by particular R genes and thus define at least two disease resistance pathways and suggest that strong dependence on EDS1 or NDR1 is governed by R protein structural type rather than pathogen class.
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Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes.
TL;DR: An RPP-nonspecific locus called EDS1 appears to be a necessary component of the resistance response specified by several RPP genes and is likely to function upstream from the convergence of disease resistance pathways in Arabidopsis.
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The arms race is ancient history in Arabidopsis , the wildflower
TL;DR: The complete sequence of the Arabidopsis thaliana genome provides a framework for exploring the 'big bang' of R genes that occurred and how R genes evolved in plants from their associations with microorganisms, and for improving strategies for more sustainable deployment of disease resistance in crops.
Journal ArticleDOI
NDR1, a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen.
TL;DR: Characterization of the ndr1-1 mutation suggests that a common step exists in pathways of resistance to two unrelated pathogens, and that a hypersensitive-like response was still induced by several of the strains.
Journal ArticleDOI
Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the rpp8 locus of arabidopsis
John M. McDowell,Murali Dhandaydham,Terri A. Long,Mark G. M. Aarts,Stephen A. Goff,Eric B. Holub,Jeffery L. Dangl +6 more
TL;DR: In this paper, the RPP8 gene was cloned and the structure of alleles at this locus in resistant Landsberg erecta (L er -0) and susceptible Columbia (Col-0) accessions were compared.