E
Eric J. Jenkinson
Researcher at University of Birmingham
Publications - 92
Citations - 7231
Eric J. Jenkinson is an academic researcher from University of Birmingham. The author has contributed to research in topics: Thymocyte & Stromal cell. The author has an hindex of 45, co-authored 92 publications receiving 7112 citations. Previous affiliations of Eric J. Jenkinson include University of Tampere & St Bartholomew's Hospital.
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Journal ArticleDOI
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures.
TL;DR: It is shown that engaging the CD3/TCR complex of immature mouse thymocytes with anti-CD3 antibodies produces DNA degradation and cell death through the endogenous pathway of apoptosis.
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Cellular Interactions in Thymocyte Development
TL;DR: Alongside the functional roles of stromal cells, considerable progress is being made in unraveling the nature of the signaling pathways involved in T cell development, and identification of the pre-T cell receptor and associated signaling molecules marks an important advance.
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Lymphostromal interactions in thymic development and function
TL;DR: It is becoming increasingly clear that the generation and maintenance of thymic environments that are capable of supporting efficient T-cell development, requires complex interplay between lymphoid and stromal compartments of the thymus.
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MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus
TL;DR: These findings provide the first direct evidence that mesenchymal as well as epithelial cells are involved in T-cell development, and suggest that their involvement is stage-specific and likely to be dependent on short-range or contact-mediated interactions.
Journal ArticleDOI
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c‐Myb
Nikla R. Emambokus,Nikla R. Emambokus,Alexandros Vegiopoulos,Alexandros Vegiopoulos,Ben Harman,Eric J. Jenkinson,Graham Anderson,Jon Frampton,Jon Frampton +8 more
TL;DR: The results point to a complex involvement of c‐Myb in the regulation of proliferation and commitment within the haemopoietic hierarchy.