Erica Menegatti

TL;DR: CDMS is strongly associated with CCSVI, a scenario that has not previously been described, characterised by abnormal venous haemodynamics determined by extracranial multiple venous strictures of unknown origin.

TL;DR: PTA of venous strictures in patients with CCSVI is safe, and especially in patients in the RR group, the clinical course positively influenced clinical and QOL parameters of the associated MS compared with the preoperative assessment.

TL;DR: A significant impairment of cerebral venous drainage in patients affected by MS is demonstrated, a mechanism potentially related to increased iron stores, when compared to revised McDonald criteria as a gold standard of MS diagnosis.

TL;DR: This study of MS patients demonstrated significant haemodynamic alterations detected in veins anatomically related to plaque disposition, which should contribute towards understanding the role of altered venous flow and tissue drainage in the MS inflammatory chain, as well as in the neurodegenerative process.

TL;DR: It is demonstrated that venous outflow disturbances in the form of CCSVI significantly impact on CSF pathophysiology in patients with MS.