E
Erik Corona
Researcher at Stanford University
Publications - 9
Citations - 556
Erik Corona is an academic researcher from Stanford University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 7, co-authored 9 publications receiving 508 citations. Previous affiliations of Erik Corona include Boston Children's Hospital & Harvard University.
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Journal ArticleDOI
Gene flow from North Africa contributes to differential human genetic diversity in southern Europe
Laura R. Botigué,Brenna M. Henn,Simon Gravel,Brian K. Maples,Christopher R. Gignoux,Erik Corona,Erik Corona,Gil Atzmon,Edward R. Burns,Harry Ostrer,Carlos Flores,Jaume Bertranpetit,David Comas,Carlos Bustamante +13 more
TL;DR: The source of genetic diversity in southern Europe has important biomedical implications and it is found that most disease risk alleles from genome-wide association studies follow expected patterns of divergence between Europe and North Africa, with the principal exception of multiple sclerosis.
Journal ArticleDOI
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.
Rong Chen,Erik Corona,Erik Corona,Martin Sikora,Joel T. Dudley,Joel T. Dudley,Alexander A. Morgan,Alexander A. Morgan,Andrés Moreno-Estrada,Geoffrey B. Nilsen,David Ruau,David Ruau,Stephen E. Lincoln,Carlos Bustamante,Atul J. Butte,Atul J. Butte +15 more
TL;DR: Type 2 diabetes (T2D) demonstrated extreme directional differentiation of risk allele frequencies across human populations, compared with null distributions of European-frequency matched control genomic alleles and risk alleles for other diseases, and these patterns contribute to disparities in predicted genetic risk.
Journal ArticleDOI
Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration
Erik Corona,Rong Chen,Rong Chen,Martin Sikora,Alexander A. Morgan,Chirag J. Patel,Chirag J. Patel,Aditya Ramesh,Aditya Ramesh,Carlos Bustamante,Atul J. Butte,Atul J. Butte +11 more
TL;DR: It is found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia, and biliary liver cirrhosis, alopecia areata, bladder cancer, inflammatory bowel disease, membranous nephropathy, and vitiligo have undergone genetic risk differentiation.
Journal ArticleDOI
Extreme Evolutionary Disparities Seen in Positive Selection across Seven Complex Diseases
TL;DR: The results inform the current understanding of disease etiology, shed light on potential benefits associated with the genetic-basis of disease, and aid in the efforts to identify causal genetic factors underlying complex disease.
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Systematic correlation of environmental exposure and physiological and self-reported behaviour factors with leukocyte telomere length
TL;DR: Both environmental exposures and chronic disease-related risk factors may play a role in telomere length, and correlations between exposures, behaviours and clinical factors and changes in telitere length will require further investigation regarding biological influence of exposure.