Showing papers by "Erik G. Larsson published in 1986"
TL;DR: Twenty monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage-derived components and selected autoreactive antibodies caused synovitis, but in no case did it give rise to full-blown arthritis.
Abstract: Twenty monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage-derived components. The monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected autoreactive antibodies caused synovitis, but in no case did it give rise to full-blown arthritis.
381 citations
TL;DR: It appears that experimental arthritis induced with homologous type II collagen resembles rheumatoid arthritis in humans, both in certain clinical features and in the lack of correspondence between anti-type II collagen autoantibody titers and disease symptoms.
Abstract: Native mouse type II collagen was used for immunization of DBA/1 mice. Arthritis developed exclusively in male animals and was characterized by a variable and delayed onset, a slow and progressive development, and frequent exacerbations of disease in several joints including those that were previously affected. Titers of anti-type II collagen autoantibodies were found not to correlate well with arthritis development. It appears that experimental arthritis induced with homologous type II collagen resembles rheumatoid arthritis in humans, both in certain clinical features and in the lack of correspondence between anti-type II collagen autoantibody titers and disease symptoms.
193 citations
TL;DR: In the deciduous dentition continuous dummy-sucking is almost always associated with an anterior openbite and an increased prevalence of posterior crossbite and there is a tendency towards an anterior rotation of the mandible.
Abstract: In the deciduous dentition continuous dummy-sucking is almost always associated with an anterior openbite and an increased prevalence of posterior crossbite. Dummy-sucking in older children is very rare. The effect of earlier dummy-sucking in the permanent dentition is not very marked. However, there is a tendency towards an anterior rotation of the mandible.
102 citations
TL;DR: The observed expression of an endogeneous virus genome during oocyte maturation strengthens the hypothesis that this type of genome is active at early developmental stages.
Abstract: Fluids from 208 follicles were analyzed with respect to the concentration of estradiol and progesterone and to the presence of RD 114 retrovirus p30-related protein (rp), assuming that such a protein indicates the presence of C-virus particles in the follicular fluids. The results obtained showed that 60–80% of the follicular fluids within the same range of steroid hormone levels contained virus p30 rp. Electron microscopy showed 80-nm virus-like particles, more or less well preserved, in about half of the number of oocytes examined. Negative staining of purified follicular fluid particles showed ring-like structures with a size of 100–200 mm. It is concluded that the presence of virus p30 rp in follicular fluids is correlated neither to a certain steroid hormone concentration nor to the oocyte capability to become fertilized and cleave. The observed expression of an endogeneous virus genome during oocyte maturation strengthens the hypothesis that this type of genome is active at early developmental stages.
9 citations
TL;DR: Retrospective analysis of S-TK showed a good correlation with the course of the disease, its treatment, recurrence and final outcome of a kidney transplant patient who suffered a fatal CMV infection.
Abstract: Measurement of deoxythymidine kinase activity (S-TK) in serum is used as a marker for cytomegalovirus (CMV) infection following transplant surgery. A case is presented where a kidney transplant patient suffered a fatal CMV infection. The new antiviral drug Foscarnet® was used to treat the infection. Retrospective analysis of S-TK showed a good correlation with the course of the disease, its treatment, recurrence and final outcome.
4 citations