K
Kristofer Rubin
Researcher at Uppsala University
Publications - 166
Citations - 14139
Kristofer Rubin is an academic researcher from Uppsala University. The author has contributed to research in topics: Extracellular matrix & Integrin. The author has an hindex of 62, co-authored 166 publications receiving 13554 citations. Previous affiliations of Kristofer Rubin include Swedish University of Agricultural Sciences & University of South Carolina.
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Journal ArticleDOI
High interstitial fluid pressure — an obstacle in cancer therapy
TL;DR: Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.
Journal ArticleDOI
Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types
Carl-Henrik Heldin,Gudrun Bäckström,Arne Östman,Annet Hammacher,Lars Rönnstrand,Kristofer Rubin,Monica Nistér,Bengt Westermark +7 more
TL;DR: The different abilities of the three dimeric forms of PDGF to stimulate incorporation of [3H]TdR into human fibroblasts indicated that the major mitogenic effect ofPDGF is mediated via the B type receptor.
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PDGF receptors as cancer drug targets
TL;DR: The benefits of combining PDGF antagonists and VEGF antagonists in a mouse model of pancreatic islet cancer are shown in a report by Bergers et al.
Journal Article
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.
Kristian Pietras,Arne Östman,Mats Sjöquist,Elisabeth Buchdunger,Rolf K. Reed,Carl-Henrik Heldin,Kristofer Rubin +6 more
TL;DR: Interference with PDGF receptors, or their ligands, as a novel strategy to increase drug uptake and therapeutic effectiveness of cancer chemotherapy is suggested.
Journal Article
Inhibition of PDGF Receptor Signaling in Tumor Stroma Enhances Antitumor Effect of Chemotherapy
Kristian Pietras,Kristofer Rubin,Tobias Sjöblom,Elisabeth Buchdunger,Mats Sjöquist,Carl-Henrik Heldin,Arne Östman +6 more
TL;DR: In conclusion, this study identifies inhibition of PDGF signaling in tumor stroma as a novel, possibly general strategy for enhancement of the therapeutic effects chemotherapy.