Erik Strandberg

TL;DR: These properties allow application of the GALA method not only to macroscopically aligned samples but also to randomly oriented samples, which has important practical advantages, and is shown to be energetically unfavorable.

TL;DR: Different approaches are outlined here, with an emphasis on solid state NMR methods, to study the structures of antimicrobial peptides in lipid bilayers as well as the effect of these peptides on model membranes.

TL;DR: The membrane-disruptive antimicrobial peptide PGLa is found to change its orientation in a dimyristoyl-phosphatidylcholine bilayer when its concentration is increased to biologically active levels.

TL;DR: It is seen that pyrene prefers a position inside the lipid membrane near the headgroups and has no tendency to diffuse from one monolayer of the membrane to the other, and the normal of the molecular plane is aligned nearly perpendicular to the bilayer normal.

TL;DR: Changes in peptide conformation and membrane alignment observed here by OCD seem to be functionally relevant, as they can be correlated with the membrane perturbing activities of the three antimicrobial and cell-penetrating sequences.