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Erika L.F. Holzbaur
Researcher at University of Pennsylvania
Publications - 198
Citations - 20976
Erika L.F. Holzbaur is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Dynein & Microtubule. The author has an hindex of 75, co-authored 178 publications receiving 17917 citations. Previous affiliations of Erika L.F. Holzbaur include Alkermes & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Mutant dynactin in motor neuron disease.
Imke Puls,Catherine Jonnakuty,Bernadette H. LaMonte,Erika L.F. Holzbaur,Mariko Tokito,Eric A. Mann,Mary Kay Floeter,Kimberly Bidus,Dennis Drayna,Shin J. Oh,Robert H. Brown,Christy L. Ludlow,Kenneth H. Fischbeck +12 more
TL;DR: The results show that dysfunction of dynactin-mediated transport can lead to human motor neuron disease.
Journal ArticleDOI
Differential regulation of dynein and kinesin motor proteins by tau.
TL;DR: The differential modulation of dynein and kinesin motility suggests that MAPs can spatially regulate the balance of microtubule-dependent axonal transport.
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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
TL;DR: An important role for optineurin is established as an autophagy receptor in parkin-mediated mitophagy and demonstrates that defects in a single pathway can lead to neurodegenerative diseases with distinct pathologies.
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Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.
TL;DR: Autophagosome biogenesis and maturation in primary neurons is a constitutive process that is spatially and temporally regulated along the axon.
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Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.
Bernadette H. LaMonte,Karen Wallace,Beth A. Holloway,Spencer S. Shelly,Jennifer Ascaño,Mariko Tokito,Thomas J. Van Winkle,David Howland,Erika L.F. Holzbaur +8 more
TL;DR: A mouse model that confirms the critical role of disrupted axonal transport in the pathogenesis of motor neuron degenerative disease is described, and dynamitin overexpression was found to disassemble dynactin, a required activator of cytoplasmic dynein, resulting in an inhibition of retrograde axonal Transport.