E
Erin Y. Fenton
Researcher at University of Saskatchewan
Publications - 6
Citations - 233
Erin Y. Fenton is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Reelin & Dentate gyrus. The author has an hindex of 6, co-authored 6 publications receiving 195 citations.
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Journal ArticleDOI
The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus
April L. Lussier,Katherina A. Lebedeva,Erin Y. Fenton,Axel Guskjolen,Hector J. Caruncho,Lisa E. Kalynchuk +5 more
TL;DR: The hypothesis that reelin plays a role in the pathogenesis of depression is supported and reelin could be an important target for the development of novel therapeutics for the treatment of depression.
Journal ArticleDOI
Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation.
Erin Y. Fenton,Neil M. Fournier,April L. Lussier,Raquel Romay-Tallon,Hector J. Caruncho,Lisa E. Kalynchuk +5 more
TL;DR: This article showed that depression-like behavior in rats treated with corticosterone develops in concert with decreased dendritic complexity in newborn hippocampal granule neurons and decreased reelin expression in the proliferative subgranular zone of the dentate gyrus.
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Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression.
TL;DR: It is demonstrated that peripheral etanercept has antidepressant effects that are accompanied by a restoration of cognitive function, hippocampal neurogenesis, and GABAergic plasticity, and suggested that a normalization of reelin expression in the dentate gyrus could be a key component underlying these novel antidepressant effects.
Journal ArticleDOI
Serotonin 2A receptor clustering in peripheral lymphocytes is altered in major depression and may be a biomarker of therapeutic efficacy
Tania Rivera-Baltanas,José M. Olivares,Jose Ramon Martinez-Villamarin,Erin Y. Fenton,Lisa E. Kalynchuk,Hector J. Caruncho,Hector J. Caruncho +6 more
TL;DR: 5-HT2A receptor clusters in peripheral lymphocytes are altered in major depression, partially reversed by antidepressant treatment, and may be considered a putative biomarker of therapeutic efficacy in major depressed.
Journal ArticleDOI
The effect of chronic corticosterone on fear learning and memory depends on dose and the testing protocol.
TL;DR: A relationship between stress intensity and testing conditions that should be taken into account when assessing the effect of stress on fear memories is suggested.