Ernst Conzelmann

TL;DR: The gene vitamin K epoxide reductase complex subunit 1 (VKORC1), which encodes a small transmembrane protein of the endoplasmic reticulum, is identified, by using linkage information from three species, to be involved in two heritable human diseases.

TL;DR: Atherogenic lipoproteins stimulate O2- formation and induction of apoptosis in HUVECs and RA, and may thereby influence the pathogenesis of atherosclerosis.

TL;DR: A specific racemase for alpha-methylacyl-CoAs, which had previously been studied in rat liver, has now been demonstrated also in human tissues, and the human enzyme cross-reacts with a polyclonal antiserum against the rat liver racemases.

TL;DR: A very sensitive and convenient radiometric assay, with 2-methyl[2-(3)H]acyl-CoAs as substrates, was developed, which showed the mechanism involves abstraction of a proton in the alpha-position of the fatty acid.

TL;DR: The results showed that in addition to an earlier described multifunctional isomerase-hydratase-dehydrogenase enzyme from rat liver peroxisomes (perMFE-I), another MFE exists in rat liver each catalyse sequential hydratase and dehydration reactions of beta-oxidation but through reciprocal stereochemical courses.