E
Erwin H. Ludwig
Researcher at National and Kapodistrian University of Athens
Publications - 5
Citations - 991
Erwin H. Ludwig is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Juvenile hemochromatosis & Hemochromatosis. The author has an hindex of 2, co-authored 5 publications receiving 969 citations.
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Journal ArticleDOI
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.
George Papanikolaou,Mark E. Samuels,Erwin H. Ludwig,Marcia L.E. MacDonald,Patrick Franchini,Marie-Pierre Dubé,Lisa Andres,Julie MacFarlane,Nikos Sakellaropoulos,Marianna Politou,Elizabeta Nemeth,Jay Thompson,Jenni Risler,Catherine Zaborowska,Ryan Babakaiff,C Radomski,Terry D Pape,Owen Davidas,John Christakis,Pierre Brissot,Gillian Lockitch,Tomas Ganz,Michael R. Hayden,Y. Paul Goldberg +23 more
TL;DR: The positional cloning of the locus associated with juvenile hemochromatosis is reported and the identification of a new gene crucial to iron metabolism is identified, now called HFE2, whose protein product the authors call hemojuvelin.
Patent
Juvenile hemochromatosis gene (HFE2A), expression products and uses thereof
Mark E. Samuels,Erwin H. Ludwig,Marcia L.E. MacDonald,Patrick Franchini,Y P Goldberg,Rajender Kamboj,George Papanikolaou +6 more
TL;DR: Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic compounds, along with methods of treating and/or ameliorating diseases in human patients are disclosed.
Patent
Novel therapeutic target for treating vascular diseases, dyslipidemias and related disorders
Alison J. Brownlie,Sherrie Tafuri,Ryan R. Brinkman,Chagnovich Daniel,Aurobindo Chatterjee,Donaldson Gary C,Marie-Pierre Dube,Y P Goldberg,Jerva Leonard F,Lafrenier Ronald G,Erwin H. Ludwig,Mark E. Samuels,Chenyan Wu,Michael R. Hayden +13 more
TL;DR: In this article, the authors present compositions and methods for modulating HDL levels and/or treating a vascular disease, dyslipidemia or a related disorder in a patient in need thereof.
Patent
Jugendliches Hämochromatose-Gen (HFE2A), Expressionsprodukte und Verwendungen davon
Mark E. Samuels,Erwin H. Ludwig,Marcia L.E. MacDonald,Patrick Franchini,Y P Goldberg,Rajender Kamboj +5 more
Patent
Gene d'hemochromatose juvenile (hfe2a), produits d'expression et leurs utilisations
Mark E. Samuels,Erwin H. Ludwig,Marcia L.E. MacDonald,Patrick Franchini,Y P Goldberg,Rajender Kamboj,George Papanikolaou +6 more
TL;DR: The authors concerne des sequences de polynucleotide and polypeptide for HFE2A, ainsi que des mutations associees a l'hemochromatose juvenile, des procedes d'utilisation de celles-ci for le criblage and l'identification d'agents for le traitement de maladies liees au metabolisme du fer, y compris de petits composes organiques.