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Escolastico Aguilera-Tejero
Researcher at University of Córdoba (Spain)
Publications - 108
Citations - 3269
Escolastico Aguilera-Tejero is an academic researcher from University of Córdoba (Spain). The author has contributed to research in topics: Parathyroid hormone & Calcitriol. The author has an hindex of 29, co-authored 105 publications receiving 2953 citations.
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Journal ArticleDOI
Calcium Deficiency Reduces Circulating Levels of FGF23
María E. Rodríguez-Ortiz,Ignacio González López,Juan R. Muñoz-Castañeda,Julio M. Martinez-Moreno,Alan Peralta Ramírez,Carmen Pineda,Antonio Canalejo,Philippe Jaeger,Escolastico Aguilera-Tejero,Mariano Rodriguez,Arnold J. Felsenfeld,Yolanda Almaden +11 more
TL;DR: In parathyroidectomized rats, an increase in dietary calcium for 10 days increased serum calcium, with an associated increase in FGF23, decrease in calcitriol, and no change in phosphorus, which suggests that hypocalcemia reduces the circulating concentrations of FGF 23.
Journal ArticleDOI
Calcimimetic R-568 Decreases Extraosseous Calcifications in Uremic Rats Treated with Calcitriol
Ignacio González López,Escolastico Aguilera-Tejero,Francisco J. Mendoza,Yolanda Almaden,José Pérez,David Martin,Mariano Rodriguez +6 more
TL;DR: In uremic rats, R-568 reduces elevated PTH levels without inducing vascular calcification, prevents calcitriol-induced vascular calcifying, and decreases mortality.
Journal ArticleDOI
The effect of calcitriol, paricalcitol, and a calcimimetic on extraosseous calcifications in uremic rats
Ignacio González López,Francisco J. Mendoza,Escolastico Aguilera-Tejero,José Pérez,Fatima Guerrero,David Martin,Mariano Rodriguez +6 more
TL;DR: When used in combination with paricalcitol, AMG 641 provided excellent control of secondary hyperparathyroidism and prevented mortality associated with the use of vitamin D derivatives without causing tissue calcification.
Journal ArticleDOI
Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo
Ignacio González López,M. Encarnación Rodríguez-Ortiz,Yolanda Almaden,Fatima Guerrero,A. Montes de Oca,Carmen Pineda,Vicky Shalhoub,Mariano Rodriguez,Escolastico Aguilera-Tejero +8 more
TL;DR: The results show a direct and an indirect effect of PTH on FGF23 secretion, the former through changes in calcitriol concentrations, and Klotho expression in the kidney decreased after parathyroidectomy but was restored by hormone supplementation.
Journal ArticleDOI
Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells.
Addy Montes de Oca,Fatima Guerrero,Julio M. Martinez-Moreno,Juan Antonio Madueño,Carmen Herencia,Alan Peralta,Yolanda Almaden,Ignacio González López,Escolastico Aguilera-Tejero,Kristina Gundlach,Janine Büchel,Mirjam E. Peter,Jutta Passlick-Deetjen,Mariano Rodriguez,Juan R. Muñoz-Castañeda +14 more
TL;DR: In conclusion, magnesium transport through the cell membrane is important to inhibit VSMC calcification in vitro and inhibition of Wnt/β-catenin by magnesium is one potential intracellular mechanism by which this anti-calcifying effect is achieved.