J
Julio M. Martinez-Moreno
Researcher at University of Córdoba (Spain)
Publications - 36
Citations - 1698
Julio M. Martinez-Moreno is an academic researcher from University of Córdoba (Spain). The author has contributed to research in topics: Vascular smooth muscle & Kidney disease. The author has an hindex of 19, co-authored 33 publications receiving 1291 citations. Previous affiliations of Julio M. Martinez-Moreno include Sofia University & Autonomous University of Madrid.
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Journal ArticleDOI
Calcium Deficiency Reduces Circulating Levels of FGF23
María E. Rodríguez-Ortiz,Ignacio González López,Juan R. Muñoz-Castañeda,Julio M. Martinez-Moreno,Alan Peralta Ramírez,Carmen Pineda,Antonio Canalejo,Philippe Jaeger,Escolastico Aguilera-Tejero,Mariano Rodriguez,Arnold J. Felsenfeld,Yolanda Almaden +11 more
TL;DR: In parathyroidectomized rats, an increase in dietary calcium for 10 days increased serum calcium, with an associated increase in FGF23, decrease in calcitriol, and no change in phosphorus, which suggests that hypocalcemia reduces the circulating concentrations of FGF 23.
Journal ArticleDOI
FGF23 Fails to Inhibit Uremic Parathyroid Glands
Rocio Canalejo,Antonio Canalejo,Julio M. Martinez-Moreno,M. Encarnación Rodríguez-Ortiz,Jose C. Estepa,Francisco J. Mendoza,Juan R. Muñoz-Castañeda,Victoria Shalhoub,Yolanda Almaden,Mariano Rodriguez +9 more
TL;DR: In hyperparathyroidism secondary to renal failure, the parathyroid cells resist the inhibitory effects of FGF23, perhaps as a result of the low expression of F GF23 receptor 1 and Klotho in this condition.
Journal ArticleDOI
Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells.
Addy Montes de Oca,Fatima Guerrero,Julio M. Martinez-Moreno,Juan Antonio Madueño,Carmen Herencia,Alan Peralta,Yolanda Almaden,Ignacio González López,Escolastico Aguilera-Tejero,Kristina Gundlach,Janine Büchel,Mirjam E. Peter,Jutta Passlick-Deetjen,Mariano Rodriguez,Juan R. Muñoz-Castañeda +14 more
TL;DR: In conclusion, magnesium transport through the cell membrane is important to inhibit VSMC calcification in vitro and inhibition of Wnt/β-catenin by magnesium is one potential intracellular mechanism by which this anti-calcifying effect is achieved.
Journal ArticleDOI
Magnesium modulates parathyroid hormone secretion and upregulates parathyroid receptor expression at moderately low calcium concentration
María E. Rodríguez-Ortiz,Antonio Canalejo,Carmen Herencia,Julio M. Martinez-Moreno,Alan Peralta-Ramírez,Pablo Perez-Martinez,Juan F. Navarro-González,Mariano Rodriguez,Mirjam E. Peter,Kristina Gundlach,Sonja Steppan,Jutta Passlick-Deetjen,Juan R. Muñoz-Castañeda,Yolanda Almaden +13 more
TL;DR: Mg reduces PTH secretion mainly when a moderate low calcium concentration is present; Mg also modulates parathyroid glands function through upregulation of the key cellular receptors CaR, VDR and FGF23/Klotho system.
Journal ArticleDOI
Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats
Juan M. Díaz-Tocados,Alan Peralta-Ramírez,Alan Peralta-Ramírez,María E. Rodríguez-Ortiz,Ana I. Raya,Ignacio González López,Carmen Pineda,Carmen Herencia,Addy Montes de Oca,Noemi Vergara,Sonja Steppan,M. Victoria Pendón-Ruiz de Mier,Paula Buendía,Andrés Carmona,Julia Carracedo,Juan F. Alcala-Diaz,João M. Frazão,Julio M. Martinez-Moreno,Antonio Canalejo,Arnold J. Felsenfeld,Mariano Rodriguez,Escolastico Aguilera-Tejero,Yolanda Almaden,Juan R. Muñoz-Castañeda +23 more
TL;DR: Results of this study suggested that the protective effect of magnesium on vascular calcification was not limited to its action as an intestinal phosphate binder since magnesium administered intraperitoneally also decreased vascular calcifying.