E
Eugene I. Shakhnovich
Researcher at Harvard University
Publications - 473
Citations - 26389
Eugene I. Shakhnovich is an academic researcher from Harvard University. The author has contributed to research in topics: Protein folding & Folding (chemistry). The author has an hindex of 82, co-authored 454 publications receiving 24773 citations. Previous affiliations of Eugene I. Shakhnovich include University of Pennsylvania & Russian Academy of Sciences.
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Phase diagram of random copolymers.
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Entropic stabilization of proteins and its proteomic consequences.
TL;DR: This study discovered a novel entropic mechanism of protein thermostability due to residual dynamics of rotamer isomerization in native state and demonstrated its immediate proteomic implications.
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Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria.
Shimon Bershtein,Adrian W.R. Serohijos,Sanchari Bhattacharyya,Michael Manhart,Jeong-Mo Choi,Wanmeng Mu,Jingwen Zhou,Eugene I. Shakhnovich +7 more
TL;DR: By apparently distinguishing between self and non-self proteins, protein homeostasis imposes an immediate and global barrier to the functional integration of foreign genes by decreasing the intracellular abundance of their products.
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Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases
TL;DR: The testable hypothesis of “specificity via differential activation” as a way for the cell to control kinase specificity is proposed as well as structural and biochemical characterizations of prokaryotic and eukaryotic PKs.
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A structure-based method for derivation of all-atom potentials for protein folding.
TL;DR: A method for deriving all-atom protein folding potentials is presented and tested on a three-helix bundle protein, as well as on hairpin and helical sequences, suggesting that a potential of this form eventually could be found that folds multiple, unrelated proteins at the atomic level of detail.