Eugene I. Shakhnovich

TL;DR: A theoretical method for solving systems of coupled differential equations that describe the kinetics of complicated reaction networks in which a molecule having multiple reaction sites reacts irreversibly with multiple equivalents of a ligand (reagent).

TL;DR: In this paper, replica field theory is used to predict the phase structure of globular random heteropolymers with quenched cross-links, and the cross-link formation is attributed to micro-phase separation of the pre-gel state with crosslinks forming at the microphase interfaces, followed by a second-order transition to a sequence-stabilized globular state.

TL;DR: Emerging synergism between data and modeling provides first robust answers to the evolution of complex systems and organisms on all scales--from sequences to organisms and populations.

TL;DR: In this paper, the authors examined the relationship between sidechain geometry and sidechain packing, using an all-atom Monte Carlo simulation to sample the large space of sidechain conformations, and found that excluded volume constraints reduce the size of conformational space by many orders of magnitude, the number of allowed conformations is still large.

TL;DR: In this article, the nematic/isotropic (N/I) phase diagram and orientational ordering in heteropolymers consisting of stiff and flexible segments by field theory was studied. And it was shown that a finite and small variance in sequence disorder is sufficient to destroy orientation ordering; in the lyotropic case, the presence of sequence disorder triples the coexistence density difference compared with that of stiff homopolymers at similar conditions.