E
Eugene P. Rhee
Researcher at Harvard University
Publications - 136
Citations - 10089
Eugene P. Rhee is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Kidney disease. The author has an hindex of 37, co-authored 104 publications receiving 8118 citations. Previous affiliations of Eugene P. Rhee include National Institutes of Health & Kaiser Permanente.
Papers
More filters
Journal ArticleDOI
Metabolite profiles and the risk of developing diabetes
Thomas J. Wang,Martin G. Larson,Martin G. Larson,Ramachandran S. Vasan,Ramachandran S. Vasan,Susan Cheng,Susan Cheng,Susan Cheng,Eugene P. Rhee,Eugene P. Rhee,Elizabeth L. McCabe,Elizabeth L. McCabe,Gregory D. Lewis,Gregory D. Lewis,Caroline S. Fox,Caroline S. Fox,Paul F. Jacques,Céline Fernandez,Christopher J. O'Donnell,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen A Carr,Vamsi K. Mootha,Vamsi K. Mootha,Jose C. Florez,Jose C. Florez,Amanda Souza,Olle Melander,Clary B. Clish,Robert E. Gerszten,Robert E. Gerszten +30 more
TL;DR: Findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment.
Journal ArticleDOI
Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease
Orlando M. Gutiérrez,Tamara Isakova,Eugene P. Rhee,Anand Shah,Julie Holmes,Gina Collerone,Harald Jüppner,Myles Wolf +7 more
TL;DR: It is concluded that FGF-23 levels increase early in CKD before the development of serum mineral abnormalities and are independently associated with serum phosphate, Fe(PO4), and calcitriol deficiency.
Journal ArticleDOI
Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
Susan Cheng,Eugene P. Rhee,Martin G. Larson,Gregory D. Lewis,Elizabeth L. McCabe,Elizabeth L. McCabe,Dongxiao Shen,Melinda J. Palma,Lee D. Roberts,Andre Dejam,Amanda Souza,Amy Deik,Martin Magnusson,Caroline S. Fox,Caroline S. Fox,Christopher J. O'Donnell,Christopher J. O'Donnell,Christopher J. O'Donnell,Ramachandran S. Vasan,Olle Melander,Clary B. Clish,Robert E. Gerszten,Thomas J. Wang,Thomas J. Wang +23 more
TL;DR: Biochemical profiling identified circulating metabolites not previously associated with metabolic traits and experimentally interrogating one of these pathways demonstrated that excess glutamine relative to glutamate, resulting from exogenous administration, is associated with reduced metabolic risk in mice.
Journal ArticleDOI
Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
Eugene P. Rhee,Susan Cheng,Susan Cheng,Martin G. Larson,Geoffrey A. Walford,Gregory D. Lewis,Gregory D. Lewis,Elizabeth L. McCabe,Elizabeth L. McCabe,Elaine Yang,Laurie A. Farrell,Caroline S. Fox,Caroline S. Fox,Christopher J. O'Donnell,Christopher J. O'Donnell,Steven A. Carr,Ramachandran S. Vasan,Jose C. Florez,Jose C. Florez,Clary B. Clish,Thomas J. Wang,Thomas J. Wang,Robert E. Gerszten,Robert E. Gerszten +23 more
TL;DR: A relationship between lipid acyl chain content and diabetes risk is identified and how lipid profiling could aid in clinical risk assessment is demonstrated.
Journal ArticleDOI
2-Aminoadipic acid is a biomarker for diabetes risk
Thomas J. Wang,Thomas J. Wang,Thomas J. Wang,Debby Ngo,Nikolaos Psychogios,Andre Dejam,Martin G. Larson,Ramachandran S. Vasan,Anahita Ghorbani,Anahita Ghorbani,John F. O'Sullivan,Susan Cheng,Susan Cheng,Eugene P. Rhee,Eugene P. Rhee,Sumita Sinha,Elizabeth L. McCabe,Caroline S. Fox,Caroline S. Fox,Caroline S. Fox,Christopher J. O'Donnell,Christopher J. O'Donnell,Christopher J. O'Donnell,Jennifer E. Ho,Jose C. Florez,Jose C. Florez,Martin Magnusson,Kerry A. Pierce,Amanda Souza,Yi Yu,Christian Carter,Peter E. Light,Olle Melander,Clary B. Clish,Robert E. Gerszten,Robert E. Gerszten +35 more
TL;DR: It is suggested that 2-AAA is a marker of diabetes risk and a potential modulator of glucose homeostasis in humans and is not well correlated with other metabolite biomarkers of diabetes, such as branched chain amino acids and aromatic amino acids.