E
Eva Martínez-Pinilla
Researcher at University of Oviedo
Publications - 52
Citations - 1910
Eva Martínez-Pinilla is an academic researcher from University of Oviedo. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 21, co-authored 48 publications receiving 1453 citations. Previous affiliations of Eva Martínez-Pinilla include Spanish National Research Council & International Sleep Products Association.
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Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors
M. Ruth Pazos,Nagat Mohammed,Hector Lafuente,Martín Santos,Eva Martínez-Pinilla,Estefanía Moreno,Elsa M. Valdizán,Elsa M. Valdizán,Julián Romero,Angel Pazos,Angel Pazos,Rafael Franco,Rafael Franco,Cecilia J. Hillard,Francisco J. Alvarez,José Martínez-Orgado +15 more
TL;DR: It is demonstrated that CBD exerts robust neuroprotective effects in vivo in HI piglets, modulating excitotoxicity, oxidative stress and inflammation, and that both CB₂ and 5HT(1A) receptors are implicated in these effects.
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Health Benefits of Methylxanthines in Cacao and Chocolate
TL;DR: Palatability and health benefits of methylxanthines, in general, and theobromine, in particular, have further contributed to sustain one of the most innocuous and pleasant habits: chocolate consumption.
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Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors
Eva Martínez-Pinilla,Katia Varani,Irene Reyes-Resina,Edgar Angelats,Edgar Angelats,Fabrizio Vincenzi,Carlos Ferreiro-Vera,Julen Oyarzabal,Enric I. Canela,Enric I. Canela,José L. Lanciego,Xavier Nadal,Gemma Navarro,Gemma Navarro,Pier Andrea Borea,Rafael Franco,Rafael Franco +16 more
TL;DR: It is confirmed that CBD does not bind with high affinity to the orthosteric site of the human CB2R where the synthetic cannabinoid, [3H]-WIN 55,212-2, binds, and CBD was, however, able to produce minor but consistent reduction in the homogeneous binding assays in living cells using the fluorophore-conjugatedCB2R-selective compound, CM-157.
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The relevance of theobromine for the beneficial effects of cocoa consumption
TL;DR: Theobromine, which is found in higher amounts than caffeine, seems to be behind several effects attributed to cocoa intake, and deserves attention as one of the most attractive molecules in cocoa.
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Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization.
TL;DR: This review focuses on the convergent, complementary and telling evidence showing that homo- and heteromers of class A GPCRs exist in transfected cells and, more importantly, in natural sources.