Julen Oyarzabal

TL;DR: A cell-based screening strategy is described that has allowed us to identify compounds with ATR inhibitory activity in the nanomolar range that are being tested for cancer chemotherapy and are also very potent against ATM, ATR and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).

TL;DR: The CHEMDNER corpus is presented, a collection of 10,000 PubMed abstracts that contain a total of 84,355 chemical entity mentions labeled manually by expert chemistry literature curators, following annotation guidelines specifically defined for this task.

TL;DR: The results underline Salermide's promise as an anticancer drug and provide evidence for the molecular mechanism through which Sirt1 is involved in human tumorigenesis.

TL;DR: The data supporting the use of PDE inhibitors as cognitive enhancers are summarized and the possible mechanisms of action underlying these effects are discussed.

TL;DR: This task allowed a comparative assessment of the performance of various methodologies using a carefully prepared collection of manually labeled text prepared by specially trained chemists as Gold Standard data, and expected that the tools and resources resulting from this effort will have an impact in future developments of chemical text mining applications.